Access to Polycyclic Azepino[5,4,3-cd ]indoles via a Gold-Catalyzed Post-Ugi Dearomatization Cascade

The Journal of Organic Chemistry
Yi HeErik V Van der Eycken

Abstract

The development of a rapid and diverse access to complex natural product-like 3,4-fused indole scaffolds has always attracted considerable attention from synthetic and medicinal communities. We herein disclose a modular and straightforward protocol to prepare the densely substituted polycyclic azepino[5,4,3-cd]indole scaffolds. This synthetic process involves an Ugi four-component reaction from easily available starting materials and a gold-catalyzed post-Ugi domino dearomatization/Michael addition sequence, enabling facile access to the highly functionalized azepino[5,4,3-cd]indole core with excellent chemo-, regio-, and diastereoselectivity.

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Citations

May 13, 2021·Organic & Biomolecular Chemistry·Ziying ZhangQilin Wang

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