Access to Treatment for Hepatitis B Virus Infection - Worldwide, 2016

MMWR. Morbidity and Mortality Weekly Report
Yvan J-F HutinMarc Bulterys

Abstract

Worldwide, an estimated 257 million persons are living with chronic hepatitis B virus (HBV) infection (1). To achieve the World Health Organization (WHO) goals for elimination of HBV infection worldwide by 2030, defined by WHO as 90% reduction in incidence and 65% reduction in mortality, access to treatment will be crucial. WHO estimated the care cascade* for HBV infection, globally and by WHO Region. The patent and licensing status of entecavir and tenofovir, two WHO-recommended medicines for HBV treatment, were examined using the Medicines Patent Pool MedsPaL† database. The international price of tenofovir was estimated using WHO's global price reporting mechanism (GPRM), and for entecavir from a published study (2). In 2016, among the estimated 257 million persons infected with HBV worldwide, approximately 27 million (10.5%) were aware of their infection, an estimated 4.5 million (16.7%) of whom were on treatment. In 2017, all low- and middle-income countries (LMICs) could legally procure generic entecavir, and all but two LMICs could legally procure generic tenofovir. The median price of WHO-prequalified generic tenofovir on the international market fell from $208 per year in 2004 to $32 per year in 2016. In 2015, the lowes...Continue Reading

References

Sep 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harvey AlterFabien Zoulim
Mar 31, 2018·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory Collaborators

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Citations

Mar 29, 2019·Clinical Obstetrics and Gynecology·Kendra R Sylvester-Armstrong, Patrick Duff
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