Accessibility of the iodopsin chromophore.

Biochimica Et Biophysica Acta
H MatsumotoT Yoshizawa

Abstract

Iodopsin can replace its chromophore (11-cis retinal) by added 9-cis retinal, resulting in the formation of isoiodopsin. NaBH4 bleaches iodopsin in the dark. In a relatively low concentration of digitonin, the scotopsin (the protein moiety of chicken rhodopsin) removes 11-cis retinal from iodopsin in the dark. These facts suggest that the linkage of the chromophore to opsin in the iodopsin molecule (presumably a Schiff-base linkage) is accessible to these reagents, which is different from the situation in rhodopsin.

References

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Jan 1, 1983·Biophysics of Structure and Mechanism·T Yoshizawa, Y Fukada
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Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Christopher T SchaferDavid L Farrens
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