Accessing the transcriptional status of selenoproteins in skin cancer-derived cell lines.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Assis EckerDaniel Ardisson-Araujo

Abstract

Selenoproteins are selenocysteine (Sec)-containing proteins that exhibit numerous physiological functions, mainly antioxidative activities. Studies have suggested that several human selenoproteins play an important role in tumor initiation and progression, including melanoma. Using RNA-seq data set from Sequence Reads Archive (SRA) experiments published at the National Center for Biotechnology Information (NCBI), we determined and compared the transcriptional levels of the 25 selenoproteins-coding sequences found in 16 human-derived melanoma cell lines and compared to four melanocyte controls. 15 selenoprotein-coding genes were found to be expressed in melanoma and normal melanocyte cells, and their mRNA levels varied among the cell lines. All melanoma cells analyzed with BRAF or NRAS mutations presented upregulated levels of SELENOI, TXNRD1, and SELENOT transcripts and downregulated levels of SELENOW and SELENON transcripts in comparison with melanocytes controls. Moreover, SELENOW, SELENON, SELENOI, TXNRD1, and SELENOT-coding transcripts were affected when BRAF-mutated A375 cells were treated with CPI203, A771726 or Vorinostat drugs. Our results indicate that melanoma cells can modify, in a different manner, the selenoprotein...Continue Reading

References

Nov 1, 1973·Journal of the National Cancer Institute·D J GiardW P Parks
May 1, 1994·The Journal of Investigative Dermatology·B C PenceD M Dunn
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·K HirotaJ Yodoi
May 24, 2000·The Journal of Biological Chemistry·P WieselM A Perrella
Aug 22, 2000·The Journal of Investigative Dermatology·U B HofmannD J Ruiter
Feb 13, 2001·Clinical and Experimental Dermatology·R C McKenzie
Jul 25, 2003·The Journal of Laboratory and Clinical Medicine·Jennifer RaffelGarth Powis
Jun 19, 2004·Free Radical Biology & Medicine·Mohamed A NasrAlan M Diamond
Feb 3, 2005·Cancer Biology & Therapy·John E Biaglow, Richard A Miller
May 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Veda Diwadkar-NavsariwalaAlan M Diamond
Nov 4, 2006·Seminars in Cancer Biology·Go FujinoHidenori Ichijo
Nov 10, 2006·Seminars in Cancer Biology·Elias S J Arnér, Arne Holmgren
Jan 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luca GrumolatoYoussef Anouar
Mar 11, 2009·Biochimica Et Biophysica Acta·Dolph L HatfieldVadim N Gladyshev
Mar 18, 2009·Biochimica Et Biophysica Acta·Pin Zhuo, Alan M Diamond
Sep 15, 2009·Antioxidants & Redox Signaling·Valentina A ShchedrinaVadim N Gladyshev
Nov 26, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aniruddha SenguptaDolph L Hatfield
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Dec 18, 2010·Nature·David Solit, Charles L Sawyers
Feb 18, 2014·European Journal of Cell Biology·Nives MoroPaola Zigrino
Jan 1, 2012·Biomolecules·Béla PappAgota Apáti
Jul 6, 2014·Physiological Reviews·Vyacheslav M LabunskyyVadim N Gladyshev
Aug 1, 2013·Biomolecular Concepts·Jonathan N Gonzalez-FloresPaul R Copeland
Jan 13, 2015·Investigative Ophthalmology & Visual Science·Osamu SakaiShiro Amano
Jun 11, 2015·Antioxidants & Redox Signaling·Marcus CebulaElias S J Arnér
Jul 18, 2015·Pigment Cell & Melanoma Research·Pamela B CassidyPhilip J Moos
Sep 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrew G CoxWolfram Goessling
Feb 9, 2017·Frontiers in Pharmacology·Loh Teng-Hern TanBey-Hing Goh
Aug 9, 2017·Oxidative Medicine and Cellular Longevity·Dhaval Patel, Stephan N Witt
Sep 2, 2017·OncoTargets and Therapy·Eva Muñoz-CouseloJosé Perez-Garcia
Jan 14, 2018·Free Radical Biology & Medicine·Martin BertzAnna P Kipp

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