PMID: 8964609Jan 1, 1996Paper

Accessory cell requirements for T lymphocyte activation and interferon-gamma production in peripheral lymph nodes

Immunology Letters
C M HodgsonI Kimber

Abstract

Allergen-activated draining lymph node cells (LNC) isolated from mice exposed topically to the contact allergen oxazolone mount vigorous proliferative responses and secrete substantial amounts of interferon-gamma (IFN-gamma) when cultured with the T lymphocyte mitogen concanavalin A (con A). In contrast, although naive LNC prepared from untreated mice display con A-driven proliferative responses of comparable magnitude, they produce only very low levels of IFN-gamma. Secretion of IFN-gamma by con A-stimulated naive LNC was augmented significantly by the addition to culture of a small number of syngeneic dendritic cells (DC), under conditions where there was no influence on the vigour of proliferative responses and where the exogenous DC themselves failed to produce IFN-gamma. Augmentation of IFN-gamma production was not observed when exogenous populations depleted of DC were added to culture. It is proposed that discrete aspects of the primary activation of naive T lymphocytes display differential requirements for accessory cells and that the development of IFN-gamma producing cells necessitates sufficient numbers of dendritic cells.

References

Oct 1, 1992·The Journal of Experimental Medicine·C P LarsenR P Lowry
Oct 1, 1991·Immunological Reviews·R L CoffmanR Chatelain
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C Hauser, S I Katz

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Citations

Nov 18, 2003·Photodermatology, Photoimmunology & Photomedicine·M R PraterS D Holladay
Dec 2, 2008·PLoS Pathogens·Lai Guan NgWolfgang Weninger
May 15, 2015·PloS One·Kenneth LetendreJudy L Cannon

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