PMID: 109533Jun 1, 1979

Accessory cell requirements for the generation of cytolytic T lymphocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
C T Lutz, F W Fitch

Abstract

A system is presented that may simplify the study of accessory cell requirements for CTL generation. Cortisone resistant (CR) thymocytes containing alloreactive CTL precursors do not respond to allogeneic tumor cells unless non-T accessory cells are added to culture. In addition, splenic T cells do not respond to allogeneic tumor cells in the absence of non-T accessory cells. These accessory cells share several properties of macrophages.

Related Concepts

Cell Adhesion
Cell Separation
Adreson
Immunologic Tumoricidal Activities
Dose-Response Relationship, Immunologic
Therapeutic Immunosuppression
Lymphocyte Cooperation
Macrophage
Mice, Inbred C57BL
Mice, Inbred DBA

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