Accessory cell tumour: a clinicopathological study of 16 aggressive tumours containing EBV-positive Hodgkin and Reed-Sternberg-like giant cells

Histopathology
Kae ShimazakiM Kikuchi

Abstract

Lymph nodes contain non-lymphoid accessory cells including follicular dendritic cells and interdigitating dendritic cells. Functionally, these cells belong to the category of immune accessory cells involved in antigen presentation to B or T-lymphocytes. Neoplastic proliferation of these cells is very uncommon. We present here the clinicopathological features of 16 cases of accessory cell tumour. We performed electron microscopic and immunohistochemical examinations, and used in-situ hybridization for EBV-encoded RNA (ISH-EBV) to detect the EBV genome in 11 cases, and Southern blot analysis to assess EBV clonality in two cases. Tumour cells were composed of oval-to-spindle cells arranged in diffuse, vague storiform, fascicular and sometimes whorled patterns in a background of small lymphocytes. In all cases, binucleated or multinucleated Hodgkin and Reed-Sternberg-like giant cells were encountered. Staining for CD68 was positive in all cases. CD21, CD35, Ki-M4p, Ki-FDC1p, and S100 exhibited variable reactivity. ISH-EBV yielded positive labelling in seven of 11 cases, of which five exhibited EBV only in Hodgkin and Reed-Sternberg-like giant cells. Southern blot analysis showed clonality of EBV terminal repeats (EBV-TR) in the two...Continue Reading

References

Apr 1, 1992·Immunological Reviews·M H Kosco, D Gray
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Oct 1, 1990·Immunological Reviews·J G TewA K Szakal
Jan 1, 1987·Leukemia Research·T KodamaM Hayami
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·A CarboneL Santi
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J GerdesA Ziegler
Aug 1, 1996·The American Journal of Surgical Pathology·B Perez-OrdonezJ Rosai
Jul 1, 1997·American Journal of Hematology·R FonsecaJ G Strickler
Apr 9, 1998·Virchows Archiv : an International Journal of Pathology·C Beham-SchmidG Höfler
Oct 10, 1998·American Journal of Hematology·R FonsecaA Tefferi
Feb 20, 1999·Journal of the American Academy of Dermatology·I J LeeH S Chi
Mar 26, 1999·Head & Neck·S DesaiN Jambhekar
Apr 10, 1999·Annals of Diagnostic Pathology·C FisherM E Smith

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Citations

Dec 31, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gabriela GualcoCarlos E Bacchi
Jun 13, 2013·Critical Reviews in Oncology/hematology·Caner SayginNukhet Tuzuner
Mar 28, 2006·Pathology, Research and Practice·Abbas Agaimy, Peter H Wünsch
Apr 23, 2009·The Journal of International Medical Research·Q PanY H Chen
Sep 11, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jinfen Wang, Clive R Taylor

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