Accessory function of Kupffer cells in the antigen-specific blastogenic response of an L3T4+ T-lymphocyte clone to Listeria monocytogenes.

Infection and Immunity
S H Gregory, E J Wing

Abstract

The function of Kupffer cells in the development of protective immunity to infection by Listeria monocytogenes is controversial. To determine their role in antilisterial host defenses, Kupffer cells were separated from other nonparenchymal cells of the liver by centrifugation on a metrizamide gradient followed by adherence to glass or plastic. The resultant highly enriched Kupffer cell population supported the antigen-specific blastogenic response [( 3H]thymidine incorporation) of cloned L3T4+ T lymphocytes to L. monocytogenes in vitro. Blastogenesis was dependent upon the duration of the incubation period, the concentration of the antigen, and the number of Kupffer cells in culture. Maximum reactivity was greater than that observed when the same T-cell population was incubated with adherent peritoneal exudate cells and antigen under optimal conditions. The addition of antibodies specific for murine interleukin-1 beta to cocultures of Kupffer cells and T lymphocytes eliminated the antigen-stimulated incorporation of [3H]thymidine, indicating a requirement for interleukin-1. Analysis of the culture supernatants demonstrated that, in addition to interleukin-1, granulocyte-macrophage colony-stimulating factor, interleukin-6, and g...Continue Reading

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Citations

Jul 4, 2001·Clinical Microbiology Reviews·J A Vázquez-BolandJ Kreft
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen H GregoryEdward J Wing
Jan 4, 2003·Nature Reviews. Immunology·Ian Nicholas Crispe
Sep 25, 2015·Metallomics : Integrated Biometal Science·J MartitzL Schomburg
Jul 30, 2009·Seminars in Immunopathology·Eszter NemethCliona O'Farrelly
Jul 31, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin HolubStephen H Gregory
Feb 20, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·A R IshaqF Noor
Dec 8, 2017·Cells·Maria Alice Freitas-LopesGustavo B Menezes
Apr 1, 1997·Toxicology and Applied Pharmacology·S M FurstA J Gandolfi

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