Accidental intrathecal administration of vincristine

The American Journal of Forensic Medicine and Pathology
Adriana D'AddarioMiguel Angel Riudavets

Abstract

We describe a case of accidental intrathecal administration of vincristine in a 33-year-old man with clinical diagnosis of acute lymphocytic leukemia. The patient died 20 days after receiving the drug. Clinically, the patient developed acute ascending paralysis with motor and sensory dysfunctions, and respiratory failure. Neuropathological investigation revealed lesions in spinal cord, roots, and cerebellum characterized by rarefaction of the neuropil, axonal, and myelin degeneration, accompanied by macrophagic infiltration.

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Citations

Nov 25, 2011·British Journal of Anaesthesia·R OniaK Kassler-Taub
Oct 4, 2011·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Peter Gilbar
Nov 18, 2017·Paediatric Anaesthesia·Ronald S LitmanPhoebe Mainland
Nov 10, 2013·Cancer Nursing·Peter J Gilbar
Oct 1, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Cristina Pueyo-LópezEsther Gómez de Salazar-López de Silanes
Nov 5, 2020·Regional Anesthesia and Pain Medicine·Eugene R ViscusiFrederick S Southwick

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