PMID: 2486848Jul 1, 1989Paper

Accidental overdose of multiple chemotherapeutic agents

The Korean Journal of Internal Medicine
I S KimB Speck

Abstract

A 35-year-old man with refractory low grade diffuse centroblastic centrocytic non-Hodgkin's lymphoma was treated accidentally with an overdose of multiple chemotherapeutic agents. He was given adriamycin 50 mg/m2 and cyclophosphamide 350 mg/m2 for 6 days followed by 4 days of vincristine 1 mg/m2 and bleomycin 10 mg/m2. He was transferred when he developed pancytopenia, fever, severe mucositis, ileus and peripheral neuropathy. He was treated with broad spectrum antibiotics, red cell and single donor platelet transfusions and strict parenteral nutrition. In addition, he was given a continuous infusion of 400 micrograms daily human recombinant granulocyte macrophage-colony stimulating factor (rh GM-CSF) for 17 days. Intractable severe bleeding from his oral mucositis necessitated treatment with a continuous infusion of 8-ornithine-vasopressin for 8 days. He recovered and could be discharged home after 36 days of hospitalization with normal blood counts and without severe sequelae.

References

Jan 1, 1979·Clinical Toxicology·O C Grush, S K Morgan
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·I A ChoonaraC C Bailey
Sep 30, 1987·Toxicology and Applied Pharmacology·J D InnisA Hurwitz
Aug 1, 1982·American Journal of Clinical Oncology·P R Jochimsen

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Citations

Oct 20, 2004·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Daniel J FranceJames A Whitlock
Mar 25, 2020·Indian Journal of Surgical Oncology·Kartik Chandra MandalMala Bhattacharya

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