Accommodative ciliary body and lens function in rhesus monkeys, I: normal lens, zonule and ciliary process configuration in the iridectomized eye

Investigative Ophthalmology & Visual Science
Mary Ann CroftP L Kaufman

Abstract

The underlying causes of presbyopia, and the functional relationship between the ciliary muscle and lens during aging are unclear. In the current study, these relationships were studied in rhesus monkeys, whose accommodative apparatus and age-related loss of accommodation are similar to those in humans. Centripetal ciliary body and lens equator movements were measured during accommodation in 28 eyes of 21 rhesus monkeys (ages, 5.7-26 years) by goniovideography. Ultrasound biomicroscopy was performed in 21 eyes of 17 monkeys. Narrowing of the angle between the anterior aspect of the ciliary body and the inner aspect of the cornea was used as a surrogate indicator of forward ciliary body movement during accommodation. Average centripetal ciliary body movement in older eyes (age > or =17 years, n = 16) was approximately 20% (0.09 mm) less than in young eyes (age, 6-10 years, n = 6), but not enough to explain the 60% (0.21 mm) loss in centripetal lens movement nor the 76% (10.2 D) loss in accommodative amplitude. Average forward ciliary body movement was 67% (49 degrees ) less in older (n = 11) versus young (n = 6) eyes. Maximum accommodative amplitude correlated significantly with the amplitude of centripetal lens movement (0.02 +...Continue Reading

Citations

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Jan 5, 2013·Investigative Ophthalmology & Visual Science·Kathryn RichdaleKarla Zadnik
Jun 8, 2013·Investigative Ophthalmology & Visual Science·Mary Ann CroftPaul L Kaufman
Jun 8, 2013·Investigative Ophthalmology & Visual Science·Mary Ann CroftPaul L Kaufman
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Feb 17, 2021·Investigative Ophthalmology & Visual Science·Mary Ann Croft, Paul L Kaufman

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