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Accounting for biases in riboprofiling data indicates a major role for proline and not positive amino acids in stalling translation

bioRxiv

Jun 11, 2014

Carlo G Artieri, Hunter B Fraser

Abstract

The recent advent of ribosome profiling – sequencing of short ribosome-bound fragments of mRNA – has offered an unprecedented opportunity to interrogate the sequence features responsible for modulating translational rates. Nevertheless, numerous analyses of the first riboprofiling datas...read more

Mentioned in this Paper

Molecular Profiling
In Vivo
Genetic Translation Process
Sequencing
probe gene fragment
Silo (Dataset)
Profile (Lab Procedure)
Peptides
Proline
Ribosomes
19
2
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Accounting for biases in riboprofiling data indicates a major role for proline and not positive amino acids in stalling translation

bioRxiv

Jun 11, 2014

Carlo G Artieri, Hunter B Fraser

PMID: 990006221

DOI: 10.1101/006221

Abstract

The recent advent of ribosome profiling – sequencing of short ribosome-bound fragments of mRNA – has offered an unprecedented opportunity to interrogate the sequence features responsible for modulating translational rates. Nevertheless, numerous analyses of the first riboprofiling datas...read more

Mentioned in this Paper

Molecular Profiling
In Vivo
Genetic Translation Process
Sequencing
probe gene fragment
Silo (Dataset)
Profile (Lab Procedure)
Peptides
Proline
Ribosomes
19
2

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