May 14, 2020

Evolutionary Dynamics And Geographic Dispersal Of Beta Coronaviruses In African Bats

BioRxiv : the Preprint Server for Biology
Babatunde Olanrewaju MotayoP. A. Akinduti

Abstract

Bats have been shown to serve as reserviour host of various viral agents including coronaviruses. They have also been associated with the novel coronavirus SARS-CoV2. This has made them an all important agent for CoV evolution and transmission. Our objective in this study was to investigate the dispersal, phylogenomics and evolution of betacoronaviruses ({beta}CoV) among African bats. Three data sets were generated from sequences of the partial RNA depedent RNA polymerase (RdRP) gene of Bat coronaviruses from seven African, three Asian, and four European countries. Phylogenetic trees was infered using MEGA Vs 7, Phylogeography and Evolutionary analysis were carried out, using Markov Chain Monte Carlo (MCMC) implemented in BEAST, and visualised with SPREAD3. Results showed that majority of the African strains fell within lineage D. Evolutionary rate of the African Bt{beta}CoV was 1.301 x 10-3, HPD (1.064 x 10-3 to 1.434 x 10-3), the MCC tree of the African strains showed two clades, lineage D, and lineage C. The TMRCA for lineage D strains was 1972, 95% HPD (1951 to 1990), and 2010, 95% HPD (2006 to 2014) for the South African strains. There were intercontinental dispersal of BtCoV from China and Hong Kong into Central and South...Continue Reading

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Mentioned in this Paper

Study
Fluctuation
Size
Genome
Genes
Trees (plant)
Cryptoblepharus
Evaluation
Genomics
Lizards

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