Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling

ENeuro
Teemu Aitta-AhoJohn Apergis-Schoute

Abstract

Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the underlying circuits that influence such processes are unclear. Although NAc cholinergic interneurons (CINs) comprise only a small proportion of NAc neurons, their local impact on reward-based processes provides a candidate cell population for investigating the neural underpinnings of satiety. The present research therefore aimed to determine the role of NAc-CINs in motivation for food reinforcers in relation to satiety signaling. Through bidirectional control of CIN activity in mice, we show that when motivated by food restriction, increasing CIN activity led to a reduction in palatable food consumption while reducing CIN excitability enhanced food intake. These activity-dependent changes developed only late in the session and were unlikely to be driven by the innate reinforcer strength, suggesting that CIN modulation was instead impacting the cumulative change in motivation underlying satiety signaling. We propose that on a circuit level, an overall increase in inhibitory tone onto NAc...Continue Reading

Citations

Nov 23, 2018·Frontiers in Psychiatry·David A WissPedro Rada

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Datasets Mentioned

BETA
AB1588

Methods Mentioned

BETA
PCR
biopsy

Software Mentioned

Chroma
DREADD
Patch
ImageJ
ABET II
Igor Pro
- Master
Axograph

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