Accumulating daily-varied dose distributions of prostate radiation therapy with soft-tissue-based kV CT guidance.

Journal of Applied Clinical Medical Physics
Andrew GodleyX Allen Li

Abstract

Even with daily image guidance based on soft tissue registration, deviations of fractional doses can be quite large due to changes in patient anatomy. It is of interest to ascertain the cumulative effect of these deviations on the total delivered dose. Daily kV CT data acquired using an in-room CT for five prostate cancer patients were analyzed. Each daily CT was deformably registered to the planning CT using an in-house tool. The resulting deformation field was used to map the delivered daily dose onto the planning CT, then summed to obtain the cumulative (total delivered) dose to the patient. The delivered cumulative values of prostate D100 on average were only 2.9% less than their planned values, while the PTV D95 were 3.6% less. The delivered rectum and bladder V70s can be twice what was planned. The less than 3% difference between delivered and planned prostate coverage indicates that the PTV margin of 5 mm was sufficient with the soft-tissue-based kV CT guidance for the cases studied.

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Citations

Apr 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tara RosewallMichael Milosevic
Jan 19, 2016·Mathematical Biosciences and Engineering : MBE·Subhadip Paul, Prasun Kumar Roy
Oct 21, 2016·The British Journal of Radiology·Slav Yartsev, Glenn Bauman
May 12, 2016·Journal of Applied Clinical Medical Physics·Wen LiPing Xia
Apr 8, 2021·Radiation Oncology·Nina I NiebuhrAsja Pfaffenberger

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Methods Mentioned

BETA
irradiate

Software Mentioned

Insight Toolkit

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