PMID: 9183736Jun 5, 1997Paper

Accumulation and proliferation of adult leg muscle precursors in Manduca are dependent on innervation

Journal of Neurobiology
C Consoulas, R B Levine

Abstract

During metamorphosis, the larval thoracic legs of the moth Manduca sexta are replaced by new adult legs. The leg motoneurons do not die after the loss of the larval muscles, but persist to innervate the new adult leg muscles (Kent and Levine, 1988). The adult muscles form from myoblasts that originate in specific production sites within the legs and migrate to the sites of muscle formation, where they accumulate, proliferate, and fuse to form myofibers (Consoulas et al., 1996b). Throughout adult leg muscle development, there is a close association between nerves and the developing muscles, suggesting a role for the nervous system in myogenesis (Consoulas et al., 1996a). This prediction was confirmed and the role of the nervous system clarified in the present study by cutting the larval leg nerves prior to metamorphosis. Although myoblasts were generated and migrated normally in the operated leg, they failed to accumulate in the appropriate regions. The myoblasts did not die, but failed to proliferate and remained in the denervated legs as dispersed cells or as aggregates in inappropriate regions. In about 26% of cases, this resulted in the formation of adult legs that lacked muscles. In the remaining cases, however, delayed reg...Continue Reading

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Citations

Jul 14, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Roy, K VijayRaghavan
Feb 13, 2001·Brain Research Bulletin·C ConsoulasR B Levine
Sep 21, 2011·Biological Reviews of the Cambridge Philosophical Society·Ashley W SeifertMalcolm Maden
Mar 30, 2004·The Journal of Comparative Neurology·Susan J HendricksDavid L Hill
Jul 19, 2002·The Journal of Comparative Neurology·Joanne Pearce, C K Govind
Feb 7, 1998·Journal of Neurophysiology·J PearceC K Govind
Mar 21, 2000·The Journal of Comparative Neurology·C Consoulas
Oct 17, 2002·Journal of Neurobiology·Graciela A Unguez, Harold H Zakon
Oct 6, 2020·Tissue Engineering. Part B, Reviews·Jacqueline Clark Ludwig, Barry Andrew Trimmer
Dec 25, 2004·Developmental Biology·Joyce J Fernandes, Haig Keshishian
Jul 10, 2010·Arthropod Structure & Development·Steffen Harzsch, Sabine Kreissl

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