PMID: 9649602Jul 3, 1998Paper

Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues

The Journal of Nutrition
M K Piskula, J Terao

Abstract

Absorption of orally administered (-)-epicatechin (EC) in rats was studied to obtain plasma pharmacokinetic profiles of EC metabolites. Rats were administered 172 micromol/kg body weight of EC, and blood was collected from the tail for 8 h after administration. Seven groups of compounds possessing the basic structure of EC were identified by using a combination of enzymatic hydrolysis, HPLC and electron impact mass spectrometry. Metabolites were quantified with a new, simple and sensitive method using HPLC with electrochemical detection. Ingested EC was absorbed from the alimentary tract and was present in the rat common blood circulation in the form of glucuronide and/or sulfate conjugates. The activity of conjugative enzymes in rat tissues was studied. The highest activity of glucuronosyltransferase was found in the intestinal mucosa of both of the small and large intestine; the highest activity of phenolsulfotransferase occurred in the liver, and that of catechol-O-methyl transferase was found in the liver and kidney. It has been proposed that the first detoxification step of dietary EC, namely, glucuronidation, occurs at the level of the intestinal mucosa in rats, and EC enters the common blood circulation exclusively in th...Continue Reading

References

Jul 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R MehtaP Millburn
Sep 1, 1992·Free Radical Biology & Medicine·N CotelleJ C Wallet
Mar 1, 1990·Chemical & Pharmaceutical Bulletin·M KoizumiK Kobashi
Nov 15, 1974·Nature·G M PowellC G Curtis
Jul 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A M Hackett, L A Griffiths
Dec 1, 1980·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I C Shaw, L A Griffiths
Oct 1, 1995·Clinical Pharmacology and Therapeutics·U Fuhr, A L Kummert
Apr 1, 1995·Free Radical Research·C A Rice-EvansJ B Pridham
Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Jan 1, 1996·Free Radical Biology & Medicine·S A van AckerA Bast
Feb 1, 1996·Biological & Pharmaceutical Bulletin·K OkushioY Hara
Jan 1, 1996·Free Radical Biology & Medicine·P C HollmanM B Katan
Dec 1, 1996·Bioscience, Biotechnology, and Biochemistry·T UnnoT Takeo
Jan 13, 1997·FEBS Letters·G Paganga, C A Rice-Evans
Jun 5, 1997·Nature·J JankunE Skrzypczak-Jankun
Jun 2, 1997·FEBS Letters·C ManachC Rémésy
Jul 1, 1997·The Journal of Nutrition·J SfakianosS Barnes

❮ Previous
Next ❯

Citations

Aug 5, 2000·The Journal of Nutrition·A Scalbert, G Williamson
Feb 24, 2001·Drug Metabolism and Drug Interactions·C Rice-EvansA R Rechner
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Mar 29, 2003·The American Journal of Clinical Nutrition·Jonathan M HodgsonIan B Puddey
Jul 2, 2003·Bioscience, Biotechnology, and Biochemistry·Atsushi SanoMamoru Kikuchi
Aug 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sonia BenitoM Teresa Mitjavila
Dec 1, 2004·The Journal of Nutrition·Vanessa Crespy, Gary Williamson
Dec 17, 2009·The British Journal of Nutrition·Aida SerraMaria-José Motilva
Sep 8, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ariadna SelgaJosep Lluís Torres
Apr 5, 2011·Journal of Applied Microbiology·M KutscheraA Braune
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Yoshifumi KimiraMariko Uehara
Aug 1, 2014·Bioscience, Biotechnology, and Biochemistry·Takayuki YamamotoTeruo Kawada
Sep 4, 2014·Journal of Medicinal Food·Rishipal R BansodeJianmei Yu
Mar 6, 2018·Bioscience, Biotechnology, and Biochemistry·Kaeko MurotaMariko Uehara
Jun 27, 2000·The Journal of Nutrition·M K Piskula
Apr 29, 2004·The American Journal of Clinical Nutrition·Claudine ManachLiliana Jiménez
Mar 15, 2005·Free Radical Research·Manal Abd El MohsenS Kaila Srai
Jun 24, 2006·Bioscience, Biotechnology, and Biochemistry·Mika YamadaMasayoshi Kibata
Aug 25, 2009·Journal of Cardiovascular Pharmacology·Monica GalleanoCesar G Fraga
Jun 1, 2006·Nutrition Research Reviews·Colin D Kay
May 19, 2010·International Journal of Molecular Sciences·Massimo D'ArchivioRoberta Masella
Mar 1, 2007·Expert Opinion on Drug Discovery·Suresh Kumar GuptaShyam Sunder Agrawal
Nov 12, 2013·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·A B SanthakumarI Singh
Aug 10, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Gerardo Barragán MejíaEsperanza Ontiveros Mendoza
Dec 14, 2018·Antioxidants·Yanyan LiGrace Y Chen
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Chung S YangXiaofeng Meng
Aug 2, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F CatterallC Ioannides
Sep 2, 2003·The Journal of Nutrition·Rainer CermakSiegfried Wolffram
Jan 5, 2000·The American Journal of Clinical Nutrition·J R BellS E Kasim-Karakas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.