PMID: 2495152Jan 16, 1989Paper

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

Brain Research
C BancherH M Wisniewski

Abstract

The intraneuronal accumulation of paired helical filaments in the form of neurofibrillary tangles is one hallmark of the brain pathology in Alzheimer's disease. At certain predilection sites, a small number of similar lesions are also present in the brains of the majority of aged non-demented individuals. As suggested by several studies before, these abnormal cytoskeletal structures contain determinants of microtubule-associated protein tau and ubiquitin. The present study uses a morphological classification of neurofibrillary tangles into different stages of maturation, as suggested by Alzheimer in 1911, and shows by quantitative immunocytochemistry that early stages of neurofibrillary degeneration contain abnormally phosphorylated tau. Immunoreactivity for the altered tau is seen not only in tangles but also in the cytoplasm of some nerve cells lacking neurofibrillary tangles. Similar numbers of such immunoreactive neurons without tangles are present in age-matched non-demented individuals as in Alzheimer cases, but are absent in young controls. In contrast, incorporation of an epitope, recognized by a monoclonal antibody (3-39) raised to paired helical filaments, which is directed against a determinant residing in the 50-65 ...Continue Reading

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WoodL I Binder
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Nov 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·M C HaughB H Anderton
Jan 1, 1987·Cell Motility and the Cytoskeleton·S C Papasozomenos, L I Binder
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K G MurtiV A Fried
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G PerryV Chau
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N NukinaD J Selkoe
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerJ Ulrich
Jan 1, 1986·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Oct 1, 1985·The Journal of Cell Biology·L I BinderL I Rebhun
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K S KosikD J Selkoe
Jan 1, 1984·Acta Neuropathologica·G P WangH M Wisniewski
Nov 1, 1982·Journal of the Neurological Sciences·G K Wilcock, M M Esiri

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Citations

Mar 1, 1991·Annals of Neurology·B KremerR Roos
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L KennerH Denk
Dec 1, 1994·Journal of Neuroscience Research·P K Davis, G V Johnson
Jan 1, 1994·Acta Neuropathologica·A RehmanI Grundke-Iqbal
Jan 1, 1994·Acta Neuropathologica·T DuongR S Fisher
Jan 1, 1992·Acta Neuropathologica·K IkedaS Haga
Jan 1, 1990·Acta Neuropathologica·E R PopovitchG Y Wen
Jan 1, 1991·Acta Neuropathologica·G P WangI Grundke-Iqbal
Jan 1, 1990·Acta Neuropathologica·I Grundke-IqbalJ G Joshi
Jan 1, 1989·Acta Neuropathologica·H M WisniewskiJ Currie
Apr 1, 1993·Cellular and Molecular Neurobiology·G A FaríasR B Maccioni
Jul 5, 1995·Molecular and Cellular Biochemistry·M MedinaJ Avila
Oct 20, 1999·Journal of Molecular Neuroscience : MN·S AronovI Ginzburg
Jan 1, 1993·Molecular Neurobiology·L C Doering
Dec 1, 1995·Molecular and Chemical Neuropathology·K BlennowE Vanmechelen
Aug 1, 1994·Molecular Neurobiology·K IqbalI Grundke-Iqbal

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