PMID: 8471383Mar 1, 1993Paper

Accumulation of acetone in blood during long-term anaesthesia with closed systems

British Journal of Anaesthesia
J M Strauss, J Hausdörfer

Abstract

During closed system anaesthesia with isoflurane, patients with a preoperative increase in blood concentration of acetone (> 10 mg litre-1) had a significantly greater concentration of acetone than patients with an initial normal blood concentration of acetone (P < 0.01). Flushing the closed system with a high flow of fresh gas had no effect on the blood concentration of acetone. Using a large fresh gas flow, there was no increase in blood acetone concentration. Acetone concentrations of about 50 mg litre-1 cause problems such as nausea and vomiting in the postoperative period. These symptoms occurred more frequently after closed system anaesthesia.

Citations

Jun 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A D Baxter
Oct 8, 2003·Critical Care Medicine·Amit BediJ P Howard Fee
Oct 1, 1995·Anaesthesia·J A Baum, A R Aitkenhead

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