Accumulation of advanced glycation end products and beta 2-microglobulin in fibrotic thickening of the peritoneum in long-term peritoneal dialysis patients

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Hirotaka NakamotoYasuhiko Tomino

Abstract

Characteristics of pathological alterations in long-term peritoneal dialysis (PD) are thickening of submesothelial compact (SMC) zone, small-vessel vasculopathy, and loss of mesothelial cells. Bioincompatible PD fluid plays crucial roles in peritoneal injury. Encapsulating peritoneal sclerosis (EPS), a rare and serious complication, occurred in patients on long-term PD or frequent peritonitis episodes, and ~50 % of EPS developed after PD cessation. We hypothesized that PD-related peritoneal injury factors induced by bioincompatible PD fluid accumulated in the peritoneum and might induce EPS. We therefore examined the accumulation of advanced glycation end products (AGE) and beta 2-microglobulin (β2M) in peritoneum and evaluated the relationship between their accumulation, clinical parameters, and outcome after PD cessation. Forty-five parietal peritoneal specimens were obtained from 28 PD patients, 14 uremic patients, and three patients with normal kidney function. The peritoneal equilibration test was used for peritoneal function. AGE- and β2M-expressing areas were found in vascular walls, perivascular areas, and the deep layer of the SMC in short-term PD patients and extended over the entire SMC in long-term patients. Periton...Continue Reading

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Citations

Mar 20, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·La Salete MartinsAnabela Rodrigues
Feb 24, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·UNKNOWN Journal of Artificial Organs Editorial CommitteeT Yamaoka
Feb 12, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Reo KandaYusuke Suzuki
Mar 1, 2017·Pleura and Peritoneum·Kunio KawanishiChieko Hamada

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