Accumulation of altered proteins and ageing: causes and effects

Experimental Gerontology
A R Hipkiss

Abstract

Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or both increased production or decreased elimination. Sources of altered proteins include erroneous synthesis by cytoplasmic and mitochondrial ribosomes, spontaneous deamidation, isomerization and racemization of unstable amino acids residues, damage inflicted by reactive oxygen and nitrogen species, and glycation and cross-linking by glucose and more reactive metabolites. Glycated proteins may damage mitochondria to increase production of reactive oxygen species, while highly oxidised/cross-linked polypeptides may resist proteolysis, inhibit proteasome function and induce a permanent stress response. Other possible explanations for the age-related changes in the defence systems, enzymatic and non-enzymatic, which normally counter generation of altered proteins are also discussed.

Citations

Sep 2, 2008·Biogerontology·Henrik Sejersen, Suresh I S Rattan
Oct 17, 2008·Biogerontology·Alan R Hipkiss
Mar 14, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rozalina G McCoy, K Sreekumaran Nair
Oct 3, 2013·Journal of Inorganic Biochemistry·Marta BłaszakTeresa Kowalik-Jankowska
Dec 24, 2010·The Journal of Biological Chemistry·Jun SunShu-Bing Qian
Dec 4, 2009·Molecular & Cellular Proteomics : MCP·Feliciano Priego-CapoteJean-Charles Sanchez
Oct 22, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zhen LiJoyce Royland
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Dea Slade, Miroslav Radman
Jan 24, 2013·PLoS Computational Biology·Yann Le CunffKhashayar Pakdaman
Oct 17, 2012·PloS One·Kennen B MacKaySteven G Clarke
Jan 23, 2008·Biological Chemistry·Suresh I S Rattan
Feb 15, 2012·Advances in Nutrition·Botao Liu, Shu-Bing Qian
Apr 2, 2014·Oxidative Medicine and Cellular Longevity·Daniel Ortuño-SahagúnArgelia E Rojas-Mayorquín
Mar 19, 2013·Journal of Proteomics·Ioannis P TrougakosVassilis G Gorgoulis
Feb 4, 2014·Scientifica·Aldrin V Gomes
May 13, 2014·Diabetologia·Stéphane Jaisson, Philippe Gillery
Feb 12, 2015·Translational Neurodegeneration·Ru-Jing RenAllan I Levey
May 1, 2009·Expert Review of Neurotherapeutics·Alan R Hipkiss
Jul 19, 2014·Ukrainskiĭ biokhimicheskiĭ zhurnal·K O Tokarchuk, O V Zaitseva
Mar 29, 2011·Critical Reviews in Biochemistry and Molecular Biology·Sreenivasa R Ramisetty, Michael P Washburn
Jan 5, 2016·Structure·Adam M R de GraffKen A Dill
Dec 5, 2009·Mechanisms of Ageing and Development·Gabriela ViteriEarl R Stadtman
Jun 17, 2009·Biochimica Et Biophysica Acta·Ariel B Lindner, Alice Demarez
Jul 1, 2009·Biochimica Et Biophysica Acta·Hrvoje Augustin, Linda Partridge
Nov 26, 2008·Journal of Proteomics·Yannick BrunnerJean-Charles Sanchez
Mar 19, 2008·Trends in Cell Biology·Nektarios Tavernarakis
Jul 31, 2007·Aquatic Toxicology·Michael N MooreAnthony J S Hawkins
Apr 25, 2007·Mechanisms of Ageing and Development·Alan R Hipkiss
Feb 7, 2007·American Journal of Ophthalmology·Alejandra DecaniniTimothy W Olsen
Oct 25, 2008·Mass Spectrometry Reviews·Feliciano Priego Capote, Jean-Charles Sanchez

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