Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease

Metabolism: Clinical and Experimental
Carlo M BarbagalloMaurizio R Averna

Abstract

Triglycerides (TGs) are vehicled by multiple particles with different abilities to promote atherosclerosis. Among plasma TG-rich lipoproteins (TRLs), subspecies may or may not contain apolipoprotein E (apoE) molecules: in this study, we evaluated the relative contribution of apoE-rich and apoE-poor TRLs to coronary atherosclerosis. We selected a group of males with premature coronary artery disease (CAD) without any of the classical nonlipid risk factors and/or high plasma lipid levels and evaluated the plasma concentration of TRL subspecies in comparison with healthy controls. Patients with CAD and controls had total cholesterol and TG levels within the normal range (despite slightly, even if significantly, higher TG levels in patients with CAD) and low-density lipoprotein cholesterol levels near optimal values. Nevertheless, patients with CAD had significantly lower high-density lipoprotein cholesterol, smaller low-density lipoprotein peak particle size, and a reduced HDL2b subfraction than controls. In addition, we observed higher concentrations of total TRL in patients with CAD together with a selective increase in apoE-rich particles. All these data were confirmed after correction for TG levels. We also investigated which ...Continue Reading

References

Oct 1, 1992·European Heart Journal·M R AvernaA Notarbartolo
Aug 3, 1991·The American Journal of Cardiology·G Assmann, H B Brewer
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A Austin
Feb 21, 1991·The American Journal of Medicine·R M Krauss
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T A MuslinerR M Krauss
Jan 1, 1986·Methods in Enzymology·A V NicholsT A Musliner
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Aug 1, 1981·Archives of Internal Medicine·T GordonT R Dawber
Jun 15, 1994·Annals of Internal Medicine·C C Walden, R A Hegele
Jan 1, 1993·Nephron·C M BarbagalloA Notarbartolo
Jun 15, 1997·Frontiers in Bioscience : a Journal and Virtual Library·J M Taylor, J Fan
Sep 20, 1997·The American Journal of Cardiology·S D KristensenE Falk
Apr 4, 1998·The American Journal of Cardiology·R M Krauss
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J S CohnJ Davignon
Dec 20, 2000·The Journal of Clinical Investigation·M M VéniantS G Young
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 11, 2001·Clinical Cardiology·J L Breslow
Mar 20, 2002·The American Journal of Cardiology·Evan A Stein
Feb 18, 2003·European Journal of Clinical Investigation·M RizzoR M Averna
Mar 5, 2003·The American Journal of Cardiology·Peter Libby, Masanori Aikawa
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Umesh N KhotEric J Topol

❮ Previous
Next ❯

Citations

Nov 16, 2013·Lipids·Agnieszka ĆwiklińskaMałgorzata Wróblewska
Apr 29, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ding RuWu Zonggui
May 1, 2021·Life·Carlo Maria BarbagalloEmilio Nardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.