PMID: 2503587Sep 1, 1989Paper

Accumulation of arachidonic acid cyclo- and lipoxygenase products in rat brain during ischemia and reperfusion: effects of treatment with GM1-lactone

Journal of Neurochemistry
A PetroniC Galli

Abstract

The aim of our study was to investigate the changes of various biochemical parameters (concentrations of lactate, free arachidonate, cyclo- and lipoxygenase products) in rat brain after ischemia and reperfusion and the effects of pretreatment with the ganglioside derivative GM1-lactone on the same parameters. Ischemia was induced by reversible occlusion of common carotid arteries for 20 min, which included a final 5 min of respiration of 5% oxygen in nitrogen. Reperfusion was obtained by removing the occlusion. Pre-ischemic conditions were obtained on sham-operated animals. Animals were killed by microwave irradiation of their heads. Brain levels of lactate and of free arachidonate were markedly increased after ischemia and returned to normal values at 5 min of reperfusion. Levels of the cyclooxygenase metabolites prostaglandin F2 alpha, 6-keto-prostaglandin F1 alpha, and thromboxane B2 were increased after ischemia, whereas levels of the lipoxygenase metabolite leukotriene C4 (LTC4) did not change. After reperfusion, a very marked increase of the cyclooxygenase products occurred but not of LTC4. Treatment with GM1-lactone prevented the elevation of cyclo- and lipoxygenase metabolites especially during reperfusion, with limited...Continue Reading

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Citations

Apr 1, 1991·Journal of Neurosurgery·F A RoddenB L Bauer
Jul 5, 1991·Brain Research·N HynesF Coceani
Jul 4, 2016·Medical Hypotheses·Iván Antonio García-MontalvoEduardo Pérez-Campos
Jan 1, 1991·Stroke; a Journal of Cerebral Circulation·W W Wendling, C Harakal
Nov 1, 1990·Stroke; a Journal of Cerebral Circulation·M S SerenA Leon
Mar 15, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jose A OspinaDiana N Krause
Apr 1, 1993·The American Journal of Physiology·C MichielsJ Remacle

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