Accumulation of boron compounds to tumor with polyethylene-glycol binding liposome by using neutron capture autoradiography

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
H YanagieM Eriguchi

Abstract

The cytotoxic effect of boron neutron capture therapy (BNCT) is due to a nuclear reaction between 10B and thermal neutrons. It is necessary to accumulate the 10B atoms to the tumor cells selectively for effective BNCT. In order to achieve an accurate measurement of 10B concentrations in the biological samples, we employed a technique of neutron capture autoradiography (NCAR) of the sliced whole-body samples of tumor bearing mice using CR-39 plastic track detectors. The CR-39 detectors attached with samples were exposed to thermal neutrons in the thermal column of the TRIGA II reactor at the Institute for Atomic Energy, Rikkyo University and thermal neutron facility of Paul Scherer Institute(PSI). We obtained NCAR images for mice injected intravenously by 10B-PEG liposome, 10B-transferrin-PEG liposome, or 10B-bare liposome. The 10B concentrations in the tumor tissue of mice were estimated by means of alpha-track density measurements. In this study, we can increase the accumulation of 10B atoms in the tumor tissues by binding polyethylene-glycol chains to the surface of liposome, which increase the retention in the blood flow and escape the phagocytosis by reticulo-endothelial systems. Therefore, we will be able to apply NCAR tec...Continue Reading

References

Apr 1, 2000·Japanese Journal of Cancer Research : Gann·O IshidaM Iwatsuru
Jul 21, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kazuo MaruyamaHironobu Yanagie

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Citations

Apr 8, 2010·Bioorganic & Medicinal Chemistry·Manabu UenoHiroyuki Nakamura
Feb 3, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ryo SuzukiKazuo Maruyama
Apr 1, 2005·Journal of Microencapsulation
Aug 3, 2007·Journal of Drug Targeting·Ryo SuzukiKazuo Maruyama
Apr 23, 2008·Expert Opinion on Drug Delivery·Hironobu YanagiëHiroyuki Takahashi
Sep 6, 2012·Expert Opinion on Drug Discovery·Laura Ciani, Sandra Ristori
Dec 18, 2007·International Journal of Pharmaceutics·Ryo SuzukiKazuo Maruyama
Nov 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
Nov 23, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
Jul 25, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H YanagieM Eriguchi
Dec 17, 2014·International Journal of Radiation Biology·Agustina PortuGisela Saint Martin
Jan 22, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A PortuG Saint Martin
Jul 7, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hironobu YanagieMasazumi Eriguchi
Nov 2, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H YanagieM Eriguchi

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