PMID: 2122879Sep 1, 1990Paper

Accumulation of c-fos mRNA in rat hippocampus during acquisition of a brightness discrimination

Behavioral and Neural Biology
W TischmeyerH Matthies

Abstract

Training rats to attain a foot-shock-motivated brightness discrimination in a Y-maze results in an early and transient increase of hippocampal c-fos mRNA levels. Maximal accumulation was observed immediately after training, returning to basal levels during the following 2 h. A similar increase was obtained when rats were subjected to a pseudotraining with an equal number of runs, but with random pairing of the choice of bright and dark alleys with foot shock. It is suggested that induction of hippocampal c-fos mRNA expression is a necessary, but not sufficient, prerequisite for the formation of long-term memory trace. This early gene expression seems rather to correspond to an initial stage induced by complex stimulus presentation of both the training and the pseudotraining procedure. The subsequent late synthesis or processing of target proteins finally contributing to the formation of a permanent trace requires the action of further convergent signals to principal cells, probably mediating reward or emotional influences.

References

Nov 23, 1987·Neuroscience Letters·M Dragunow, H A Robertson
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Citations

May 1, 1996·Behavior Genetics·J M WehnerR Paylor
Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Jul 18, 1994·Brain Research·R PaylorJ M Wehner
Aug 1, 1992·Brain Research. Molecular Brain Research·M BialyL Kaczmarek
Apr 1, 1993·Brain Research. Molecular Brain Research·C HeurteauxM Lazdunski
Oct 1, 1996·Progress in Neurobiology·D G Herrera, H A Robertson
Oct 6, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·S Davis, S Laroche
Jul 7, 2005·Behavioral Neuroscience·Justin S RhodesJohn C Crabbe
Aug 10, 2000·Neurobiology of Learning and Memory·S Peña de OrtizY Carrasquillo
May 18, 2016·Reviews in the Neurosciences·Andrew L EagleAlfred J Robison
Dec 15, 2007·Nature Protocols·Nohjin KeePaul W Frankland
Mar 1, 1993·Journal of Neuroscience Research·L Kaczmarek
Sep 9, 2015·The Journal of Cell Biology·F-Nora VögtleChris Meisinger
May 15, 2018·Frontiers in Behavioral Neuroscience·Francisco T GalloNoelia V Weisstaub
Dec 14, 1999·Clinical Endocrinology·M L ForslingA J Williams

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