Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat

Experimental Physiology
Natasha FillmoreJohn R Ussher

Abstract

What is the central question of this study? The aim was to determine whether the accumulation of ceramide contributes to skeletal muscle insulin resistance in the JCR obese rat. What is the main finding and its importance? Our main new finding is that ceramides accumulate only in slow-twitch skeletal muscle in the JCR obese rat and that reducing ceramide content in this muscle type by inhibition of serine palmitoyl transferase-1 halts the progression of insulin resistance in this rat model predisposed to early development of type 2 diabetes. Our findings highlight the importance of assessing insulin signalling/sensitivity and lipid intermediate accumulation in different muscle fibre types. It has been postulated that insulin resistance results from the accumulation of cytosolic lipid metabolites (i.e. diacylglycerol/ceramide) that impede insulin signalling and impair glucose homeostasis. De novo ceramide synthesis is catalysed by serine palmitoyl transferase-1. Our aim was to determine whether de novo ceramide synthesis plays a role during development of insulin resistance in the JCR:LA-cp obese rat. Ten-week-old JCR:LA-cp obese rats were supplemented with either vehicle or the serine palmitoyl transferase-1 inhibitor l-cyclose...Continue Reading

References

Mar 1, 1992·Diabetes Care·R A DeFronzoE Ferrannini
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
Mar 14, 2002·Diabetes, Obesity & Metabolism·David N Brindley, James C Russell
Dec 5, 2002·American Journal of Physiology. Endocrinology and Metabolism·Laura L AtkinsonGary D Lopaschuk
Jan 15, 2003·The Journal of Biological Chemistry·Jose Antonio ChavezScott A Summers
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Saumya SharmaHeinrich Taegtmeyer
Feb 1, 2006·Progress in Lipid Research·Scott A Summers
Mar 21, 2006·Biochemical Society Transactions·M S Patel, L G Korotchkina
Mar 6, 2007·The Journal of Biological Chemistry·Laura PickersgillStephen J Yeaman
May 19, 2007·The Journal of Clinical Investigation·Simon Schenk, Jeffrey F Horowitz
Oct 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Malin C LevinRobert V Farese
Oct 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Su GaoTimothy H Moran
Mar 6, 2008·American Journal of Physiology. Endocrinology and Metabolism·John J DubéBret H Goodpaster
Jun 3, 2008·Journal of Lipid Research·Tae-Sik ParkIra J Goldberg
Sep 5, 2008·The Journal of Clinical Investigation·Simon SchenkJerrold M Olefsky
Jul 25, 2009·American Journal of Physiology. Endocrinology and Metabolism·John R UssherGary D Lopaschuk
Jul 9, 2010·Lancet·Varman T SamuelGerald I Shulman
May 27, 2011·Acta Histochemica Et Cytochemica·Anabelle Silva CornachioneAna Cláudia Mattiello-Sverzut
Sep 13, 2011·Advances in Experimental Medicine and Biology·Sarah E Brice, L Ashley Cowart
Oct 21, 2011·Physiological Reviews·Stefano Schiaffino, Carlo Reggiani
Nov 3, 2011·The Journal of Clinical Investigation·Benjamin T Bikman, Scott A Summers
May 9, 2012·Cell Metabolism·Jose A Chavez, Scott A Summers
May 15, 2013·Cell Metabolism·William L HollandPhilipp E Scherer
Jul 1, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Susann FayyazBurkhard Kleuser

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Citations

Jul 7, 2016·American Journal of Physiology. Endocrinology and Metabolism·Hanin AburasaynJohn R Ussher
Jan 8, 2016·Hormone Molecular Biology and Clinical Investigation·Claire Laurens, Cedric Moro
Jun 19, 2019·Journal of Lipid Research·Jan-Bernd Funcke, Philipp E Scherer
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Paola A RamosMichael D Jensen

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