Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum

FEMS Microbiology Letters
Nadia PontsFlorence Richard-Forget

Abstract

Liquid cultures of Fusarium graminearum were supplemented with H2O2 or other oxidative compounds. The accumulation kinetics of the resulting trichothecenes were monitored. At non-lethal concentrations, the H2O2 treatments modulated toxin accumulation, dependent on the method of supplementation. When H2O2 was added at the same time as the inoculation, higher levels of toxins accumulated 30 days later. Conversely, adding H2O2 2 or 7 days after inoculation had little effect. When H2O2 was added daily over the course of the culture, the accumulation of trichothecenes was rapidly and strongly enhanced. The fungus may adapt to oxidative stress when the first exposure to H2O2 occurs at the beginning of the culture course. The highest toxin levels were measured when the H2O2 was added daily. The importance of the first hours of culture was confirmed: pre-treating conidia with H2O2 does not affect their germination kinetics but leads to a reduction in the yield of trichothecenes 40 days later. The H2O2 regulation of this trichothecene accumulation may be specific, as paraquat, another pro-oxidant compound, inhibits their production. Since H2O2 is a major component of the oxidative burst occurring in pathogen/host interactions, these dat...Continue Reading

References

Mar 1, 1970·Journal of Bacteriology·R WaxE M Kosower
Jan 1, 1983·British Journal of Clinical Pharmacology·J G KellyD G McDevitt
Jul 1, 1999·FEMS Microbiology Letters·M J Sweeney, A D Dobson
Mar 1, 2003·Microbiological Research·Gladys A LoriInés Rizzo
Nov 25, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Xiaorong ShenHerbert Ohm
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·E ZutherP Gornicki
May 7, 2004·Applied and Environmental Microbiology·Gilma S ChitarraJan Dijksterhuis
Feb 9, 2005·International Journal of Food Microbiology·Marco BeyerWafik S M Ragab
Apr 21, 2005·Mycological Research·Maria B AngelovaLyudmila S Slokoska

❮ Previous
Next ❯

Citations

Jan 27, 2010·Applied Microbiology and Biotechnology·Massimo ReverberiAnna Adele Fabbri
May 25, 2010·Applied Microbiology and Biotechnology·Massimo ReverberiCorrado Fanelli
Jun 22, 2011·Applied Microbiology and Biotechnology·Jawad MerhejChristian Barreau
Mar 14, 2012·Applied Microbiology and Biotechnology·Massimo ReverberiCorrado Fanelli
May 18, 2012·Molecular Plant-microbe Interactions : MPMI·Nguyen Van ThuatJörg Bormann
Sep 18, 2013·Critical Reviews in Microbiology·Mathilde MontibusNadia Ponts
Apr 7, 2010·Critical Reviews in Microbiology·Adeline PicotFlorence Richard-Forget
Dec 15, 2015·FEMS Microbiology Letters·Mathilde MontibusChristian Barreau
Aug 26, 2014·International Journal of Food Microbiology·Matias Pasquali, Quirico Migheli
Aug 12, 2014·International Journal of Food Microbiology·G ChitarriniM Reverberi
May 2, 2009·Fungal Genetics and Biology : FG & B·Donald M GardinerJohn M Manners
Nov 20, 2015·Frontiers in Microbiology·Nadia Ponts
Jan 3, 2013·Molecular Plant Pathology·Barbara SchermQuirico Migheli
Apr 3, 2016·Fungal Genetics and Biology : FG & B·Sheng-Hua YaoWei-Hua Tang
Jun 6, 2009·Microbiology·Donald M GardinerJohn M Manners
Apr 25, 2015·Journal of Agricultural and Food Chemistry·Davide FerrigoRoberto Causin
May 9, 2014·International Journal of Food Microbiology·Adriaan VanheuleGeert Haesaert
Aug 26, 2014·Frontiers in Human Neuroscience·Matthew D Egbert, Xabier E Barandiaran
Jan 21, 2015·Frontiers in Microbiology·Kevin J SheridanSean Doyle
Feb 26, 2009·FEMS Microbiology Letters·Nadia PontsFlorence Richard-Forget
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Davide FerrigoRoberto Causin
Jul 11, 2009·Molecular Plant-microbe Interactions : MPMI·Peter IlgenWilhelm Schäfer
Aug 24, 2017·Proteomics·Taotao LiYueming Jiang
Dec 1, 2018·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Torsten SchönebergSusanne Vogelgsang
Nov 20, 2019·Toxins·Lakshmipriya PerincherryŁukasz Stępień

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.