PMID: 9549644Apr 29, 1998Paper

Accumulation of fluconazole in scalp hair

Journal of Clinical Pharmacology
R YeatesF Scharpf

Abstract

The accumulation in scalp hair of the antimycotic triazole, fluconazole, was studied during and after administration. Fluconazole 50 mg was administered to 12 healthy subjects as a single capsule each day for 28 days. The concentration of fluconazole 5 hours after administration was measured in different 1-cm sections of scalp hair at intervals during treatment and for 6 months after the end of treatment. In each section of scalp hair the concentration of fluconazole increased during treatment and was consistently higher than values found in plasma. For example, the mean concentration in the first hair section on day 28, 19.8 micrograms/g, corresponded to a mean penetration ratio relative to plasma of 9.42. During administration, the maximal concentration of fluconazole was found in the first hair section. After cessation of administration, the measured concentrations of fluconazole decreased and greater concentrations were found in the distal hair sections, presumably as a result of hair growth. Fluconazole was detectable, however, in the hair of 9 of the 12 subjects even 6 months after treatment. The mean concentration of fluconazole in hair bulbs on day 28 was 12.1 micrograms/g (n = 6), corresponding to a mean penetration ra...Continue Reading

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Citations

Dec 22, 1999·Journal of the American Academy of Dermatology·H Cáceres-RíosB Bustamante
Jun 26, 1999·Pediatric Dermatology·A K GuptaR C Summerbell
Aug 11, 2004·American Journal of Clinical Dermatology·Aditya K GuptaMaria M Chaudhry
Dec 29, 1998·International Journal of Dermatology·F Montero-Gei
Dec 4, 2003·British Journal of Clinical Pharmacology·Lucy SasongkoAndrew J McLachlan
Sep 6, 2003·Dermatologic Clinics·Aditya K GuptaFernando Montero-Gei
Jan 8, 2000·Dermatologic Clinics·S S Raimer
Sep 1, 1999·The British Journal of Dermatology·A K GuptaR C Summerbell
Sep 7, 2000·Medical Mycology·A K Gupta, R C Summerbell

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