Accumulation of Multiple Mutations In Vivo Confers Cross-Resistance to New and Existing Integrase Inhibitors.

The Journal of Infectious Diseases
Wendy W ZhangAniqa Shahid

Abstract

Bictegravir (BIC) and cabotegravir (CAB) are the latest available HIV integrase inhibitors in clinical trials. The combination of major integrase inhibitor substitutions G140S/Q148H has been shown to confer high-level resistance to the approved integrase inhibitors raltegravir (RAL) and elvitegravir (EVG) but not necessarily dolutegravir (DTG). We assayed recombinant viruses made from patient-derived RNA extracts for resistance phenotype for a panel of viruses containing G140S/Q148H with additional accessory substitutions. The accumulation of multiple integrase substitutions confers high-level resistance to all 5 integrase inhibitors. There is extensive cross-resistance between DTG, BIC, and CAB (r = 0.96-0.97).

References

May 5, 2001·BMJ : British Medical Journal·UNKNOWN UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance
Jan 30, 2008·Antimicrobial Agents and Chemotherapy·Isabelle MaletAnne-Geneviève Marcelin
Apr 13, 2012·Journal of Virology·Mark A BrockmanZabrina L Brumme
Nov 5, 2014·Antimicrobial Agents and Chemotherapy·Tomokazu YoshinagaTamio Fujiwara
Feb 19, 2015·Antimicrobial Agents and Chemotherapy·Takahiro SekiTomokazu Yoshinaga
Jun 7, 2017·Retrovirology·Kaitlin AnstettMark A Wainberg

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Citations

Feb 26, 2019·Antimicrobial Agents and Chemotherapy·Robert A SmithUNKNOWN University of Washington-Dakar HIV-2 Study Group
Jul 8, 2019·The Journal of Antimicrobial Chemotherapy·Soo-Yon RheeRobert W Shafer
Aug 28, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emmanuel NdashimyeEric J Arts
Aug 31, 2019·The Journal of Biological Chemistry·Alan N Engelman
Sep 13, 2020·Viruses·Jennifer L Elliott, Sebla B Kutluay
Mar 25, 2021·Current Epidemiology Reports·Wei Li A KoayNatella Rakhmanina
Jul 11, 2021·Nature Reviews. Microbiology·Goedele N MaertensPeter Cherepanov

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