Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia.

Cancer Research
James C GarbeMark A LaBarge

Abstract

Women older than 50 years account for 75% of new breast cancer diagnoses, and the majority of these tumors are of a luminal subtype. Although age-associated changes, including endocrine profiles and alterations within the breast microenvironment, increase cancer risk, an understanding of the cellular and molecular mechanisms that underlies these observations is lacking. In this study, we generated a large collection of normal human mammary epithelial cell strains from women ages 16 to 91 years, derived from primary tissues, to investigate the molecular changes that occur in aging breast cells. We found that in finite lifespan cultured and uncultured epithelial cells, aging is associated with a reduction of myoepithelial cells and an increase in luminal cells that express keratin 14 and integrin-α6, a phenotype that is usually expressed exclusively in myoepithelial cells in women younger than 30 years. Changes to the luminal lineage resulted from age-dependent expansion of defective multipotent progenitors that gave rise to incompletely differentiated luminal or myoepithelial cells. The aging process therefore results in both a shift in the balance of luminal/myoepithelial lineages and to changes in the functional spectrum of mu...Continue Reading

References

May 1, 1980·In Vitro·M StampferA J Hackett
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BriskenR A Weinberg
Feb 5, 2000·JAMA : the Journal of the American Medical Association·C SchairerR Hoover
Feb 17, 2000·Journal of the National Cancer Institute·R K RossM C Pike
Nov 23, 2000·Nature·R A DePinho
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 6, 2002·Journal of Mammary Gland Biology and Neoplasia·Leslie Bernstein
Aug 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Biserka Mulac-JericevicOrla M Conneely
Nov 25, 2004·PLoS Biology·Graham E J RodwellStuart K Kim
Jun 2, 2006·CA: a Cancer Journal for Clinicians·Carol SmigalMichael Thun
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Oct 24, 2006·Breast Cancer Research : BCR·Greg FinakMorag Park
Nov 16, 2006·Journal of the National Cancer Institute·Tia R MilaneseDaniel W Visscher
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 10, 2007·Seminars in Nuclear Medicine·David WellDrew A Torigian
Apr 11, 2007·The Journal of Cell Biology·René VilladsenOle W Petersen
Sep 14, 2007·Breast Cancer Research : BCR·Christina YauChristopher C Benz
May 6, 2008·Cancer Cell·Min HuKornelia Polyak
Nov 20, 2009·International Journal of Cancer. Journal International Du Cancer·Valerie A McCormackIsabel Dos Santos Silva
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Mark A LaBargeMina J Bissell
Apr 13, 2010·Nature·Marie-Liesse Asselin-LabatJane E Visvader
May 7, 2010·Nature·Purna A JoshiRama Khokha
May 25, 2010·Epigenomics·Fabricio F CostaMary J C Hendrix
Feb 8, 2011·Cell Stem Cell·Theresa A ProiaCharlotte Kuperwasser
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Nov 13, 2013·Nucleic Acids Research·Marita G OverhoffCleo L Bishop
Oct 24, 2012·Breast Cancer Research : BCR·Mona ShehataJohn Stingl
Jan 19, 2013·Journal of Visualized Experiments : JoVE·Mark A LabargeMartha R Stampfer
Jan 8, 2014·Breast Cancer Research and Treatment·Heidi N HiltonC L Clarke
Apr 26, 2016·Journal of Developmental Biology·Kayla GrossCharlotte Kuperwasser
Jan 14, 2016·Breast Cancer Research : BCR·Purificación FeijooAnna Genescà
Jun 15, 2013·Stem Cells·Pasquale PellegriniGonzalez-Suarez Eva
Jul 21, 2015·Journal of Mammary Gland Biology and Neoplasia·Lisa M Arendt, Charlotte Kuperwasser
Aug 9, 2015·Journal of Mammary Gland Biology and Neoplasia·Heidi N Hilton, Christine L Clarke
Dec 2, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Paul L SeversonBernard W Futscher
Mar 31, 2015·Frontiers in Cell and Developmental Biology·Jonathan K LeeMark A LaBarge
Sep 15, 2016·Cells·Terhi O HeleniusDiana M Toivola
Nov 21, 2017·The Journal of Dairy Research·Mario BarattaEugenio Martignani
Jul 14, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jiyoung Kim, René Villadsen
Dec 12, 2012·Nature·Peter Wehrwein
Feb 14, 2019·Journal of Mammary Gland Biology and Neoplasia·Laurence FinotFrederic Dessauge
Sep 29, 2019·Scientific Reports·Lourdes González-BermúdezMariona Terradas
Dec 22, 2017·The Journal of Cell Biology·Jennifer L HuZev J Gartner
Feb 6, 2020·Molecular and Cellular Biology·Huda H Al-KhalafAbdelilah Aboussekhra
Jul 4, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jiyoung Kim, René Villadsen
Sep 27, 2019·Frontiers in Cell and Developmental Biology·Tara FresquesMark A LaBarge
Dec 28, 2018·Antioxidants·Mario BarattaEugenio Martignani
May 22, 2018·Microsystems & Nanoengineering·Junghyun KimLydia L Sohn
Dec 23, 2020·Journal of Mammary Gland Biology and Neoplasia·Fanny A Pelissier VatterHaiying Zhang
Oct 27, 2020·IScience·Agnete S T EngelsenJames B Lorens
Jun 17, 2018·Current Opinion in Cell Biology·Michael E TodhunterMark A LaBarge
Apr 26, 2018·Cell Reports·Fanny A Pelissier VatterJames B Lorens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.