Oct 1, 1976

Accumulation of nicotine in the uterine fluid of the six-day pregnant rabbit

Fertility and Sterility
J A McLachlanS Fabro

Abstract

In 6-day pregnant New Zealand White rabbits dosed intravenously with 3H-nicotine, the 3H-activity in the uterine fluid was approximately 5 to 11 times greater than that in the plasma at the corresponding times; 3H-nicotine itself accounted for most of this radioactivity. Dichlorodiphenyltrichloroethane (DDT) also accumulated in the uterine luminal fluid of 6-day pregnant rabbits, but to a lesser extent. However, nicotine or DDT accumulation did not occur in similarly treated, nonpregnant rabbits. The radioactivity in the uterine fluid of rabbits treated with 14C-isoniazid, salicylic acid, barbital, antipyrine, and caffeine was not different from that in the plasma (uterine fluid to plasma radioactivity ratios ranged between 0.67 and 1.85) in both 6-day pregnant and nonpregnant rabbits. No differences in regard to nicotine metabolism, volume of distribution, plasma disappearance, plasma protein binding, or urinary excretion were found between 6-day pregnant and nonpregnant rabbits. Accumulation of nicotine took place in the uterine luminal fluid of nonpregnant does pretreated with either progesterone or human chorionic gonadotropin, but did not occur in does pretreated with estrogen. It is possible that the accumulation of nicot...Continue Reading

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Mentioned in this Paper

Human Chorionic Gonadotropin
DRUG Screen Quant Caffeine
DDT (Insecticide)
Progesterone, (9 beta,10 alpha)-Isomer
Uterus
Estradiol, (16 alpha,17 beta)-Isomer
Quick-Pep
Progesterone
Serum Proteins
Pregnancy, Animal

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