Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Keiko NakamuraKoichi Wakabayashi

Abstract

The histological hallmark of multiple system atrophy (MSA) is accumulation of phosphorylated α-synuclein in oligodendrocytes. However, it is uncertain whether phosphorylated α-synuclein accumulates in astrocytes of MSA patients. We immunohistochemically examined the frontal and temporal lobes, basal ganglia, cerebellum, brainstem and spinal cord of patients with MSA (n = 15) and Lewy body disease (n = 20), and also in control subjects (n = 20). Accumulation of abnormally phosphorylated and aggregated α-synuclein was found in subpial and periventricular astrocytes in six of the 15 patients with MSA (40%). The structures were confined to the subpial surface of the ventro-lateral part of the spinal cord and brainstem, as well as the subependymal region of the lateral ventricles. They were not visualized by Gallyas-Braak staining, and were immunonegative for ubiquitin and p62. Immunoelectron microscopy revealed that the phosphorylated α-synuclein-immunoreactive structures in astrocytes were non-fibrillar and associated with granular and vesicular structures. The extent of phosphorylated α-synuclein-immunoreactive astrocytes was correlated with disease duration. No such structures were found in Lewy body disease or controls. Accumul...Continue Reading

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Citations

Feb 6, 2016·International Journal of Molecular Sciences·Gabor G Kovacs
Apr 22, 2016·Journal of Neural Transmission·Kurt A Jellinger, Gregor K Wenning
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Kurt A Jellinger
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Mar 1, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Shunsuke KogaDennis W Dickson
Apr 23, 2020·International Journal of Molecular Sciences·Lisa MészárosJürgen Winkler
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Jun 3, 2021·International Journal of Molecular Sciences·Panagiota Mavroeidi, Maria Xilouri

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