Accumulation of prion protein in the vagus nerve in creutzfeldt-jakob disease

Annals of Neurology
Philip KreslGabor G Kovacs

Abstract

Disease-associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease-associated prion protein (PrPSc ) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt-Jakob disease (CJD), we applied 3 different anti-PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV-2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrPSc immunodeposits with distinct morphology. Thus, PrPSc in CJD affects the vagus nerve analogously to α-synuclein in Parkinson disease. The morphologically diverse deposition of PrPSc in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrPSc . Ann Neurol 2019;85:782-787.

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Citations

Aug 10, 2019·Journal of Clinical Pathology·Gabor G Kovacs
Apr 22, 2020·The International Journal of Neuroscience·Grammatiki KatsikakiSevasti Bostantjopoulou
May 12, 2021·Nature Reviews. Neurology·Neil WatsonSuvankar Pal
Aug 18, 2021·Journal of the Neurological Sciences·Kosuke MatsuzonoShigeru Fujimoto

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