Accumulation of radioactive cardiac glycosides by various brain regions in relation to the dysrhythmogenic effect

British Journal of Pharmacology
S N DuttaE P Schoener

Abstract

Ouabain was administered at a loading dose of 3 mug/kg followed by an infusion at a rate of 1 mug/kg-1 min-1 in order to produce severe dysrhythmia in dogs within 60 minutes. Similarly, digitoxin at a loading dose of 9 mug/kg followed by an infusion at a rate of 3 mug kg-1 min-1 was administered to compare its effect with that of ouabain. 2 During the 60 min experimental period, the plasma concentrations gradually rose with the continuous infusion of these drugs. However, in comparison to the 60 min plasma value of 119+/-20 pmol/ml for ouabain and 177+/-68 pmol/ml for digitoxin, the cerebrospinal fluid (CSF) concentrations for these drugs at this time were less than 5 pmol/ml. 3 Upon termination of the experiment at 60 min it was found that kidney, liver, heart, adrenal, and the non-neural tissue in the brain such as pituitary and choroid plexus concentrated ouabain and digitoxin to give high tissue to plasma ratios. However, various neural areas of the brain (cerebellum, mesencephalon, hypothalamus, pons, and medulla) showed no preferential localization or uptake of these two glycosides. 4 Concentration of ouabain and digitoxin by the choroid plexus does not seem to affect the ionic composition of the CSF. 5 It was concluded t...Continue Reading

References

Apr 1, 1975·European Journal of Pharmacology·P R Saxena, K P Bhargava
Dec 22, 1973·Lancet·A BertlerG Wettrell
Jun 8, 1974·Lancet·R Das Gupta, P F Binnion
Dec 1, 1974·The Journal of Clinical Investigation·H GaranW J Powell
Jun 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·M PollayK M Nelson
Sep 1, 1973·The Journal of Cell Biology·P M QuintonJ M Tormey
Nov 1, 1970·The American Journal of Physiology·V A LevinC S Patlak
Jun 1, 1972·British Journal of Pharmacology·B N Basu RayS N Pradhan
Jul 6, 1971·Annals of the New York Academy of Sciences·D S Lukas

Citations

May 28, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·J KuhlmannN Rietbrock
Mar 1, 1993·Journal of Veterinary Pharmacology and Therapeutics·R L Hamlin, J L Sally
Oct 2, 2014·Advanced Materials·Peng TaoTao Deng
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Jan 1, 1985·The Anatomical Record·H H TraurigN H Bass
Dec 1, 1978·Circulation Research·G H MudgeT W Smith
Mar 11, 2005·Autonomic & Autacoid Pharmacology·A T Demiryürek, S Demiryürek

Related Concepts

Metazoa
Brain
Digitoxin-Philo
Canis familiaris
Heart
Pulse Rate
Tissue Specificity
Ouabain
Potassium

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