Accumulation of SNAP-25 immunoreactive material in axons of Alzheimer's disease

Neuroreport
F DessiC Duyckaerts

Abstract

Neurofibrillary tangles and neuropil threads, both made of hyperphosphorylated tau proteins, point to an alteration of microtubules in Alzheimer's disease. The aim of this study was to test the consequences of these lesions on axoplasmic flow, which is dependent on intact microtubule assembly. We assessed the transport of synaptic proteins from the neuronal cell body to axonal terminals, using SNAP-25 (synaptosomal-associated protein of 25 kD) immunohistochemistry as a marker of impaired axonal transport. A sample from the supra-marginalis gyrus was obtained from 29 individuals over 75 years of age whose cognitive function had been prospectively assessed. Accumulation of immunoreactive material in swollen axons was observed in the white matter of severely demented individuals, and their number was correlated with the density of neurofibrillary tangles (r = 0.53, p = 0.005) and of focal Abeta deposits (r = 0.61, p = 0.001). This supports the hypothesis of a dysfunction of the cytoskeleton in Alzheimer's disease. An unexpected finding was the lack of correlation between SNAP-25 immunohistochemistry in the grey matter and the intellectual status or the density of neurofibrillary tangles, focal Abeta deposits and neuronal profiles....Continue Reading

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Citations

Jul 12, 2002·Journal of Neuroscience Research·Neelima B Chauhan, George J Siegel
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Apr 25, 2009·Acta Neuropathologica·Thomas Arendt
Jun 8, 2006·Annual Review of Biochemistry·Gorazd B Stokin, Lawrence S B Goldstein
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas M KanaanLester I Binder
Jun 23, 2012·Experimental Neurology·Nicholas M KanaanGerardo A Morfini
Mar 11, 2009·Schizophrenia Research·Clare L BeasleyWilliam G Honer
Nov 29, 2007·The Journal of Comparative Neurology·Rita GarbelliCarolina Frassoni
Dec 8, 2005·Neurobiology of Aging·Karen Hoppens GylysGregory M Cole
Jul 29, 2011·Neurobiology of Aging·Nicholas M KanaanScott T Brady
Jun 18, 2017·Life Sciences·Daniela Recabarren, Marcelo Alarcón
Nov 3, 2016·The International Journal of Neuroscience·Aneeqa Noor, Saadia Zahid
Apr 28, 2006·Neuropathology and Applied Neurobiology·C E TeunissenL Bö
Nov 2, 2017·Frontiers in Neuroscience·Andrew KneynsbergNicholas M Kanaan

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