Accumulation of the inhibitory receptor EphA4 may prevent regeneration of corticospinal tract axons following lesion

The European Journal of Neuroscience
Jez FabesStephen Bolsover

Abstract

Abstract We have examined the expression of Eph receptors and their ephrin ligands in adult rat spinal cord before and after lesion. Neurons in adult motor cortex express EphA4 mRNA, but the protein is undetectable in uninjured corticospinal tract. In contrast, after dorsal column hemisection EphA4 protein accumulates in proximal axon stumps. One of the ligands for EphA4, ephrinB2, is normally present in the grey matter flanking the corticospinal tract but after injury is markedly up-regulated in astrocytes in the glial scar. The result is that, after a lesion, corticospinal tract axons bear high levels of EphA4 and are surrounded to front and sides by a continuous basket of cognate inhibitory ephrin ligand. We suggest that a combination of EphA4 accumulation in the injured axons and up-regulation of ephrinB2 in the surrounding astrocytes leads to retraction of corticospinal axons and inhibition of their regeneration in the weeks after a spinal lesion.

References

Dec 1, 1988·Acta Neurologica Scandinavica·B Nyström, J E Berglund
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 12, 1998·Pharmacology & Therapeutics·R Zhou
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M DottoriA W Boyd
Mar 3, 1999·The European Journal of Neuroscience·C C StichelH W Müller
Apr 8, 1999·Experimental Neurology·J D MirandaS R Whittemore
Nov 30, 2000·Neuroreport·R C de CastroA M Romanic
Mar 21, 2001·Nature Reviews. Neuroscience·R Gerlai
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·O RaineteauM E Schwab
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
May 31, 2002·Nature·Tadzia GrandPréStephen M Strittmatter
Aug 21, 2002·Trends in Cell Biology·Chad A Cowan, Mark Henkemeyer
Mar 18, 2003·Nature Neuroscience·Anna Aurora BattagliaIsabella Gavazzi
Jun 10, 2003·The Journal of Comparative Neurology·Julie M SrogaPhillip G Popovich
Sep 15, 2004·Current Opinion in Cell Biology·Rüdiger Klein
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yona GoldshmitAnn M Turnley
Jul 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·M Douglas BensonLuis F Parada
Aug 9, 2005·Journal of Neurotrauma·Margarita Irizarry-RamírezJorge D Miranda

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Citations

Jul 19, 2013·Neuroscience Bulletin·Yi-Min Yuan, Cheng He
Dec 9, 2009·Expert Reviews in Molecular Medicine·Fardad T AfshariJames W Fawcett
Jun 6, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Klaus Wanisch, Rafael J Yáñez-Muñoz
Jan 1, 2014·Nature Reviews. Drug Discovery·Andrew W BoydMartin Lackmann
Jul 22, 2006·Nature Reviews. Neuroscience·Noam Y Harel, Stephen M Strittmatter
Aug 30, 2008·The Journal of Biological Chemistry·Roberta NoberiniElena B Pasquale
Feb 12, 2009·The Journal of Biological Chemistry·Laura MontaniMartin E Schwab
Apr 6, 2013·Journal of Neurotrauma·Mark Damien SpanevelloPerry Francis Bartlett
Jun 4, 2010·Cold Spring Harbor Perspectives in Biology·Roman J GigerMark H Tuszynski
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lynn C UsherJohn L Bixby
Sep 22, 2012·Progress in Retinal and Eye Research·Daniel M LipinskiRobert E MacLaren
Jan 10, 2016·Experimental Neurology·Larry I BenowitzJeffrey L Goldberg
Nov 2, 2011·Seminars in Cell & Developmental Biology·Tzu-Jen KaoArtur Kania
Nov 2, 2011·Seminars in Cell & Developmental Biology·Hui Miao, Bingcheng Wang
Feb 23, 2010·Experimental Neurology·Julia E HerrmannBinhai Zheng
Feb 10, 2012·Journal of Neuropathology and Experimental Neurology·Tony FrugierYona Goldshmit
Dec 18, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edmund R Hollis
Aug 21, 2007·Experimental Neurology·Gabrielle Curinga, George M Smith
Jan 20, 2007·Progress in Neurobiology·Ferdinando RossiLuigi Corvetti
Dec 17, 2009·Genesis : the Journal of Genetics and Development·Julia E HerrmannBinhai Zheng
Mar 6, 2010·Journal of Neurochemistry·Till B Puschmann, Ann M Turnley
Oct 20, 2007·Brain Research·Paolo MiganiJennifer Rodger
Apr 12, 2012·The Biochemical Journal·Ilaria LambertoElena B Pasquale
Nov 1, 2016·Journal of Neurochemistry·Masayuki Masu
May 21, 2017·The Journal of Biological Chemistry·Lies SchoonaertWim Robberecht
Jul 18, 2018·The Journal of Comparative Neurology·Karen M FisherCorinna Darian-Smith
Dec 7, 2019·Current Opinion in Neurology·Kimberly K GokoffskiPhillip Lam
Apr 14, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kimberly K GokoffskiHeidi R R Ansorge
Jul 6, 2020·Molecular Biology Reports·Max London, Eugenio Gallo
Jul 25, 2019·Frontiers in Immunology·Thayer K Darling, Tracey J Lamb
Aug 10, 2019·Frontiers in Cellular Neuroscience·Lara BielerSebastien Couillard-Despres
Feb 15, 2007·The Journal of Comparative Neurology·Marie-Eve TremblayGuy Doucet
Dec 4, 2020·Current Ophthalmology Reports·Lauren K WarehamDavid J Calkins
Feb 18, 2021·Cellular and Molecular Neurobiology·Xiaogang ChenShouguo Wang

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