Accumulation of various N-acylethanolamines including N-arachidonoylethanolamine (anandamide) in cadmium chloride-administered rat testis

Archives of Biochemistry and Biophysics
S KondoA Tokumura

Abstract

Changes in the levels of various molecular species of N-acylethanolamine in CdCl2-administered rat testis were examined. We found that the levels of various N-acylethanolamines including anandamide (N-arachidonoylethanolamine), an endogenous cannabinoid receptor ligand, were dramatically increased in CdCl2-admin-istered rat testis. Such changes were particularlyprominent for saturated and monoenoic species such as N-palmitoyl species (39-fold at 9 h) and N-stearoyl species (21-fold at 9 h), compared with unsaturated fatty acid-containing species such as anandamide (5-fold at 9 h). Noticeably, increased levels were observed of not only N-acylethanolamines but also several species of N-acylphosphatidylethanolamine, potential precursors for N-acylethanolamines. We confirmed that the rat testis microsomal fraction contains phosphodiesterase activity catalyzing the release of N-acylethanolamine from N-acylphosphatidylethanolamine and transacylase activity catalyzing the formation of N-acylphosphatidylethanolamine from phosphatidylethanolamine and phosphatidylcholine. These enzyme activities were not dramatically different in the microsomal fraction obtained from CdCl2-administered rat testis compared with that in the case of control...Continue Reading

References

Sep 27, 1979·Biochemical and Biophysical Research Communications·D E EppsH H Schmid
Oct 1, 1991·The Biochemical Journal·C M GérardM Parmentier
Jan 1, 1990·Progress in Lipid Research·H H SchmidV Natarajan
Aug 18, 1982·Biochimica Et Biophysica Acta·V NatarajanH H Schmid
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·L FacciA Leon
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SchuelS Zimmerman
Feb 9, 1993·European Journal of Pharmacology·E Fride, R Mechoulam
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C C FelderW A Devane
May 24, 1996·Chemistry and Physics of Lipids·H H SchmidV Natarajan
Feb 7, 1997·The Journal of Biological Chemistry·T BisognoV Di Marzo
Dec 1, 1996·Journal of Lipid Mediators and Cell Signalling·E V BerdyshevV Lagente
Jul 14, 1997·Chemistry and Physics of Lipids·P C SchmidH H Schmid
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Oct 30, 2001·British Journal of Pharmacology·R CapassoV Di Marzo
Mar 24, 2000·The Biochemical Journal·E V BerdyshevH H Schmid
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Kent-Olov JonssonChristopher J Fowler
Jun 21, 2005·Life Sciences·Jesse LoVermeDaniele Piomelli
Apr 22, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Iffat Ara Sonia RahmanNatsuo Ueda
May 31, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emanuela EspositoSalvatore Cuzzocrea
Aug 20, 2016·British Journal of Pharmacology·Stefania Petrosino, Vincenzo Di Marzo
Feb 4, 2003·Journal of Lipid Research·Giovanna ZoleseAnnarina Ambrosini
Aug 23, 2007·Chemistry & Biodiversity·Kazuhito TsuboiNatsuo Ueda
Aug 23, 2007·Chemistry & Biodiversity·Séverine Vandevoorde, Didier M Lambert
Nov 21, 2020·Nature Reviews. Urology·Mauro MaccarroneArcangelo Barbonetti
Dec 19, 2020·International Journal of Molecular Sciences·Stefania Petrosino, Aniello Schiano Moriello
Dec 7, 2000·Chemistry and Physics of Lipids·C J Hillard, A Jarrahian
Dec 7, 2000·Chemistry and Physics of Lipids·H S HansenG Petersen
Dec 7, 2000·Chemistry and Physics of Lipids·L De PetrocellisV Di Marzo
Jun 6, 2002·Chemistry and Physics of Lipids·Qian LiuNatsuo Ueda
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SugiuraK Waku
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H H O Schmid, E V Berdyshev
Aug 7, 2002·European Journal of Pharmacology·Barbara CostaMariapia Colleoni
Aug 17, 2002·Pharmacology & Therapeutics·Harald S HansenHenrik H Hansen
Dec 31, 2002·Chemistry and Physics of Lipids·Harald H O SchmidEvgueni V Berdyshev
Feb 26, 2008·European Journal of Pharmacology·Renato Malcher-LopesJeffrey G Tasker

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