Accuracy and diagnostic sensitivity of radiographic absorptiometry of the second metacarpal

Calcified Tissue International
S HagiwaraH K Genant

Abstract

The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black premenopausal women, 39 healthy non-black postmenopausal women, and 35 non-black osteoporotic postmenopausal females. The overall correlation between the ash weights of the entire metacarpal and the DIP values was excellent (r = 0.954, P < 0.001, SEE = 0.14, CV = 6.4%). Short-term precision error of DIP was 3.5%. Age-related bone loss determined by DIP is comparable to that of spinal and forearm DXA: annual BMD decreases were 0.46% for DIP, 0.45% for forearm, and 0.32% for the spine. DIP of the 2nd metacarpal shows a gradient of risk for spinal fracture only slightly below that of forearm DXA, but substantially below that of spinal DXA. Age-adjusted odds ratios were 1.81 for RA, 2.45 for spinal DXA, and 1.94 for forearm DXA.

Citations

Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KleerekoperE L Peterson
Jun 30, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y AbeS Honda
Aug 8, 2008·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·L KalichmanG Livshits
Apr 23, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Leonid KalichmanGregory Livshits
Aug 6, 2013·Physical Biology·A S Verkman

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