Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart

Medical Engineering & Physics
Damon J KellyGlenn R Gaudette

Abstract

Future treatment of heart disease may involve local perturbations of mechanical function, such as intramyocardial injections of angiogenic growth factors or progenitor cells. This necessitates an accurate measurement technique to determine regional heart function. We have previously developed a method to determine regional heart function using a phase correlation algorithm. However, in determining regional function over a single heartbeat it is necessary to sum displacements between many images. We have therefore incorporated a subpixel algorithm that models the result of phase correlation as a sinc function in order to increase the accuracy of our technique. This method, which we have named high density mapping (HDM), determines the subpixel displacement of 64 x 64 pixel regions from images of the heart. To determine the accuracy and precision of the technique, a high contrast image of a heart was digitally shifted 1, 2 or 3 pixels. The original and shifted images were then downsampled four times resulting in 0.25, 0.50 or 0.75 pixel shifts between the original and shifted images. The average accuracy of HDM in the digitally shifted images was 0.06 pixels, with a precision of 0.08 pixels. Effectiveness of HDM in characterizati...Continue Reading

References

Mar 17, 1999·Medical Physics·A M MuijtjensA Hasman
Dec 31, 2003·Biomaterials·Wolfram Hubertus ZimmermannThomas Eschenhagen
Feb 11, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard B ThompsonDoris A Taylor
Jan 28, 2006·Journal of Biomechanics·Evren U AzelogluGlenn R Gaudette
Feb 5, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Hassan ForooshMarc Berthod
Mar 20, 2008·Applied Optics·N Van PuymbroeckJ Taboury

❮ Previous
Next ❯

Citations

Feb 20, 2010·Biomechanics and Modeling in Mechanobiology·Jenna L BalestriniKristen L Billiar
Nov 6, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adrian R WestGeoffrey N Maksym
Aug 23, 2011·PloS One·Angela M Throm QuinlanKristen L Billiar
Nov 13, 2007·Journal of Electrocardiology·Irina A PotapovaIra S Cohen
Apr 23, 2014·Journal of Tissue Engineering and Regenerative Medicine·Ze-Wei TaoGlenn R Gaudette
Jul 15, 2015·IEEE Transactions on Medical Imaging·Colleen M WitzenburgVictor H Barocas
Nov 20, 2012·The American Journal of Pathology·Ming TaoC Keith Ozaki
Aug 30, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Amy A Claeson, Victor H Barocas
Oct 28, 2015·Circulation Research·Jacques P GuyetteHarald C Ott
Apr 24, 2020·Journal of Biomedical Materials Research. Part a·Emily R RobbinsGlenn R Gaudette
Feb 24, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Russell GarmanStefan Judex
Oct 31, 2019·Tissue Engineering. Part a·Philipp T MoserHarald C Ott
Feb 22, 2017·Biomaterials·Joshua R GershlakGlenn R Gaudette

❮ Previous
Next ❯