PMID: 11328916May 1, 2001Paper

Accuracy and safety of online clearance monitoring based on conductivity variation

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
U KuhlmannH Lange

Abstract

Haemodialysis dose has been shown to have a distinct impact upon the morbidity and mortality rate in patients on regular dialysis therapy. Accordingly, the adequacy of dialysis treatment should be guaranteed. In 200 dialysis sessions two or three +/-10% dialysate conductivity variations were applied to test patient compliance and the accuracy of an electrolyte based online clearance measurement (OCM) reflecting the total clearance of urea. Using a step profile the electrolytic clearance showed highly significant correlation with the reference data in the blood side (n=118, r=0.867, P<0.001) and dialysate side (n=118, r=0.820, P<0.001) if only reference values were taken into account for which the error in mass balance did not exceed 5%. Kt/V according to the single pool model (n=35, r=0.940, P<0.001), the equilibrated single pool variable volume kinetic model (n=36, r=0.982, P<0.001), Daugirdas formula (n=34, r=0.951, P<0.001) and direct quantification of dialysance via spent dialysate (n=26, r=0.900, P<0.001) showed outstanding correlations with electrolyte-based Kt/V at mass balance error below 5%. No adverse clinical effect of OCM was reported. Serum sodium, body weight, heart rate and breathing rate at rest, arterial pO(2) ...Continue Reading

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Citations

Jan 20, 2007·Intensive Care Medicine·Christophe RidelChristophe Vinsonneau
Mar 26, 2005·Seminars in Nephrology·Andrew J CortezSteve J Schwab
Nov 25, 2003·Kidney International·Andreas WuepperLorraine Edwards
Aug 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elizabeth J LindleyEric J Will
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May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fredrik UhlinMartin Magnusson

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