Accuracy in quantification of coronary calcification with CT: a cork-dog heart phantom study

Academic Radiology
Philip H TsengMatthew J Budoff

Abstract

Coronary artery calcium is a sensitive risk predictor of cardiac events. However, measurement of calcium foci is affected by partial-volume effects, which ultimately have an effect on accuracy and reproducibility of calcium scores. In this study, we describe the accuracy of quantification of calcium foci of known size and density using cork-dog heart phantoms. Five study phantoms were constructed from cork chests and dog hearts containing 135 calcium hydroxyapatite (CaHA) foci of known volume, mass, and concentration located in the coronary arteries or the myocardium. Hearts were separated into two groups: (1) three hearts containing large, high-density foci and (2) two hearts containing small, low-density foci. The phantoms were scanned using a standard coronary artery calcium (CAC) protocol and the volume and mean intensity of foci were measured. In group 1, the total volume of 87 CaHA foci measured was 4284 and 3779 mm(3) with electron beam computed tomography (EBCT); multidetector computed tomography (MDCT), respectively (P < .001). Both were significantly larger than the true volume (2713.9 mm(3), P < .001). In Group 2, the total volume of 57 CaHA foci measured was 592.6 and 702.9 mm(3) with EBT and MDCT, respectively (P <...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Dec 19, 2002·Journal of Computer Assisted Tomography·Matthew J BudoffHans Fisher
Jun 29, 2004·Radiology·Kirsten L BoedekerJonathan G Goldin
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May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
Jun 13, 2009·JACC. Cardiovascular Imaging·Michael BlahaKhurram Nasir

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Citations

Sep 8, 2015·Clinical Imaging·Donghee HanJames K Min

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