Abstract
The purpose of this study was to assess the accuracy of (18) F-fluorodeoxyglucose positron emission tomography ((18) FDG PET)-CT in detecting residual or recurrent disease after nonsurgical treatment for head and neck squamous cell carcinoma (HNSCC). We conducted a retrospective analysis of patients with oral cavity, oropharynx, larynx, hypopharynx, or cervical lymph node location of SCC treated with chemoradiotherapy. Twelve weeks posttreatment, (18) FDG PET-CT results were compared to histology if residual disease was suspected. Patients with complete response received a minimum of 24-month follow-up. Forty-seven patients were included with 40 months of median follow-up: 46 with a squamous cell carcinoma (SCC) at the primary site and 43 in the neck. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 86.7%, 90%, 76.5%, and 93.1%, respectively, at the primary site and 100%, 97.2%, 87.5%, 100%, respectively, in the neck. (18) FDG PET-CT seems effective in detecting residual disease and in predicting recurrent disease within the first 2 years of follow-up after nonsurgical treatment. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1271-E1276, 2016.
References
Sep 1, 1989·Head & Neck·J T ParsonsR R Million
Aug 15, 1994·Cancer·K M GrevenJ O Cappellari
Jan 21, 1993·The New England Journal of Medicine·E E VokesW K Hong
Mar 14, 2000·The Laryngoscope·W J Goodwin
Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Aug 3, 2005·American Journal of Clinical Oncology·Sue S YomDavid I Rosenthal
Apr 21, 2006·The British Journal of Oral & Maxillofacial Surgery·D KissunS N Rogers
Apr 3, 2008·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Jun 19, 2008·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M G IslesH M Mehanna
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Sep 23, 2008·The Laryngoscope·Pierre-Olivier VedrineUNKNOWN French Groupe d'Etude des Tumeurs de la Tête et du Cou Group
Dec 19, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ronan AbgralPierre Y Salaun
Feb 12, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Klaus StrobelThomas F Hany
May 19, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-Pierre PignonUNKNOWN MACH-NC Collaborative Group
Feb 4, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Carin A Uyl-de GrootOtto S Hoekstra
Aug 20, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Tejpal GuptaAshwini Budrukkar
Sep 3, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Guila DelouyaPhuc Félix Nguyen-Tan
Apr 5, 2013·The Laryngoscope·Balasubramanya RangaswamyLale Kostakoglu
Sep 17, 2013·The Oncologist·Lale KostakogluEric Genden
Aug 30, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Philippe RobinPierre-Yves Salaun
Citations
Nov 21, 2018·Head & Neck·Erin T WongShao Hui Huang
Sep 1, 2018·AJNR. American Journal of Neuroradiology·P WangaryattawanichT J Rath
Sep 25, 2019·Cancers·Kanako TakayamaMasao Murakami
Feb 26, 2020·Japanese Journal of Radiology·Takashi HiyamaTatsushi Kobayashi
Feb 7, 2018·Targeted Oncology·Valérie CochinAmaury Daste
Nov 21, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Caroline Theresa SeebauerJulian Künzel