Accuracy of [18F]FDG PET/MRI for the Detection of Liver Metastases

PloS One
Karsten BeiderwellenThomas C Lauenstein

Abstract

The aim of this study was to compare the diagnostic accuracy of [18F]FDG-PET/MRI with PET/CT for the detection of liver metastases. 32 patients with solid malignancies underwent [18F]FDG-PET/CT and subsequent PET/MRI of the liver. Two readers assessed both datasets regarding lesion characterization (benign, indeterminate, malignant), conspicuity and diagnostic confidence. An imaging follow-up (mean interval: 185±92 days) and/-or histopathological specimen served as standards of reference. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for both modalities. Accuracy was determined by calculating the area under the receiver operating characteristic (ROC) curve. Values of conspicuity and diagnostic confidence were compared using Wilcoxon-signed-rank test. The standard of reference revealed 113 liver lesions in 26 patients (malignant: n = 45; benign: n = 68). For PET/MRI a higher accuracy (PET/CT: 82.4%; PET/MRI: 96.1%; p<0.001) as well as sensitivity (67.8% vs. 92.2%, p<0.01) and NPV (82.0% vs. 95.1%, p<0.05) were observed. PET/MRI offered higher lesion conspicuity (PET/CT: 2.0±1.1 [median: 2; range 0-3]; PET/MRI: 2.8±0.5 [median: 3; range 0-3]; p<0.001) and diagnostic ...Continue Reading

References

Dec 25, 2003·JAMA : the Journal of the American Medical Association·Gerald AntochStefan G Ruehm
Oct 30, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerald AntochLutz S Freudenberg
Feb 24, 2006·Archives of Surgery·Leanne M SutherlandGuy J Maddern
Jun 26, 2009·Annals of Surgical Oncology·Stéphane Benoist, Bernard Nordlinger
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Olivio F DonatiDominik Weishaupt
Aug 5, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jeong Won LeeTae-Sung Kim
Feb 25, 2011·International Journal of Clinical Oncology·Mitsuaki TatsumiJun Hatazawa
Aug 17, 2011·Journal of Medical Imaging and Radiation Oncology·Wai-Ling ChanRobert Dura
Aug 15, 2013·Seminars in Liver Disease·Gilles MenthaPietro Majno
Sep 10, 2013·European Journal of Radiology·Karsten BeiderwellenThomas C Lauenstein
Dec 19, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Caecilia S ReinerPatrick Veit-Haibach
Jan 27, 2016·World Journal of Gastroenterology : WJG·Rafif E MattarMazen Hassanain

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Citations

Jun 28, 2016·Seminars in Ultrasound, CT, and MR·Vicky GohGary Cook
Mar 30, 2017·Annals of Nuclear Medicine·Amit SingnurkarUr Metser
Jan 25, 2018·Cancers·Anuhya KommalapatiAmit Mahipal
Apr 18, 2019·AJR. American Journal of Roentgenology·Tetsuro ArakiJyothi P Jagannathan
Nov 22, 2019·Current Radiopharmaceuticals·Riccardo LaudicellaAndrei Iagaru
Sep 20, 2020·Abdominal Radiology·Ryan D WardOnofrio Catalano
May 20, 2020·Der Radiologe·Krista Elise Suarez-WeissOnofrio A Catalano
Jun 18, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Dong ZhengJiahe Tian
Apr 2, 2020·Der Radiologe·Krista Elise Suarez-WeissOnofrio A Catalano
Mar 3, 2017·Nuclear Medicine and Molecular Imaging·Hyun Woo KwonGi Jeong Cheon
Oct 22, 2019·Seminars in Nuclear Medicine·Lale UmutluJohannes Grueneisen
Apr 7, 2021·Physics in Medicine and Biology·Matteo IppolitiChristoph Kolbitsch
Oct 19, 2016·Journal of Hepatology·Maxime RonotAndrea Frilling
Aug 14, 2021·The British Journal of Radiology·Lisa A MinDoenja M J Lambregts

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