Accuracy of an Immunochromatographic Diagnostic Test (ICT Malaria Combo Cassette Test) Compared to Microscopy among under Five-Year-Old Children when Diagnosing Malaria in Equatorial Guinea.

Malaria Research and Treatment
José-Luis PorteroJorge Cano

Abstract

Conventional malaria diagnosis based on microscopy raises serious difficulties in weak health systems. Cost-effective and sensitive rapid diagnostic tests have been recently proposed as alternatives to microscopy. In Equatorial Guinea, a study was conducted to assess the reliability of a rapid diagnostic test compared to microscopy. The study was designed in accordance with the directives of the Standards for Reporting Diagnostic Accuracy Initiative (STARD). Peripheral thick and thin films for the microscopy diagnosis and a rapid immunochromatographic test (ICT Malaria Combo Cassette Test) were performed on under five-year-old children with malaria suspicion. The ICT test detected Plasmodium spp. infection with a sensitivity of 81.5% and a specificity of 81.9% while P. falciparum diagnosis occurred with a sensitivity of 69.7% and a specificity of 73.7%. The sensitivity of the ICT test increased with higher parasitemias. The general results showed little concordance between the ICT test and microscopy (kappa = 0.28, se: 0.04). In Equatorial Guinea, the ICT Malaria Combo Cassette Test has proven to be an acceptable test to detect high P. falciparum parasitemias. However, the decrease of sensitivity at medium and low parasitemias ...Continue Reading

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Citations

Jul 31, 2012·PloS One·Luzia GonçalvesMen-Fang Shaio
Jul 31, 2013·The American Journal of Tropical Medicine and Hygiene·Juan Gabriel PiñerosSilvia Blair
Sep 26, 2013·The American Journal of Tropical Medicine and Hygiene·Sean C MurphyV Ann Stewart
Oct 15, 2014·The American Journal of Tropical Medicine and Hygiene·Din SyafruddinJ Kevin Baird
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Sep 8, 2017·Frontiers in Public Health·Joseph Joel PollakSeth J Salpeter
Jan 31, 2018·Malaria Journal·Maria GruenbergIngrid Felger

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