Accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a DENV-4 epidemic

BMC Infectious Diseases
Sibelle Nogueira BuonoraRegina P Daumas

Abstract

Early diagnosis of dengue infection is important for decision-making and timely implementation of therapeutic measures. Although rapid NS1 assays have been used for dengue diagnosis since 2008, their performance in DENV-4 cases has not yet been fully assessed. We evaluated the accuracy of NS1 Bioeasy™ immunochromatographic strip test and of three clinical criteria for dengue diagnosis. Patients presenting at an emergency care center within 72 h of an acute febrile illness during the 2013 DENV-4 epidemic in Rio de Janeiro were consecutively enrolled for clinical and laboratory evaluation. We classified patients as suspected dengue or not according to three clinical criteria: WHO 2009, WHO 1997, and INI-FIOCRUZ. Dengue diagnosis was defined by RNA detection using RT-PCR and the negative cases were negative for all dengue serotypes and also Platelia™ NS1 ELISA. We obtained accuracy indices for NS1 Bioeasy™ alone and in combination with the clinical criteria. RT-PCR for DENV-4 was positive in 148 out of 325 patients. Positive likelihood ratio, sensitivity, and specificity of NS1 Bioeasy™ with WHO 2009, WHO 1997, and INI-FIOCRUZ criteria were 22.6 (95% CI 7.2-70.6), 40.6% (95% CI 32.3-49.3), and 98.2% (95% CI 94.9-99.6); 18.3 (95% C...Continue Reading

References

Apr 1, 1990·Memórias do Instituto Oswaldo Cruz·R M NogueiraH G Schatzmayr
Oct 19, 2005·Emerging Infectious Diseases·Rita Maria Ribeiro NogueiraMarize Pereira Miagostovich
Mar 17, 2009·Cadernos de saúde pública·Maria Glória TeixeiraMaurício Lima Barreto
Jan 13, 2010·The American Journal of Tropical Medicine and Hygiene·José Luis San MartínMaría G Guzmán
Jul 14, 2010·PLoS Neglected Tropical Diseases·Monique da Rocha Queiroz LimaFlavia Barreto dos Santos
Feb 5, 2011·The American Journal of Tropical Medicine and Hygiene·Shera ChaterjiEng-Eong Ooi
May 7, 2011·Nature Reviews. Microbiology·Rosanna W PeelingSutee Yoksan
Jun 10, 2011·Memórias do Instituto Oswaldo Cruz·Rita M R Nogueira, Ana L F Eppinghaus
Apr 9, 2013·Nature·Samir BhattSimon I Hay
May 30, 2013·PloS One·Vanessa Ramos Faria SeaRoseli La Corte dos Santos
Jul 23, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Fernanda Oliveira FerrazMauro Martins Teixeira
Aug 31, 2013·PLoS Neglected Tropical Diseases·Gamaliel GutiérrezEva Harris
Oct 25, 2013·BMC Infectious Diseases·Yee-Sin LeoDavid C Lye
Nov 19, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tatiana Elias ColomboMaurício Lacerda Nogueira
Jan 22, 2014·BMC Infectious Diseases·Andrea L ConroyKevin C Kain
Apr 12, 2014·PloS One·Jessé Henrique TruppelVanete Thomaz-Soccol
Jun 25, 2014·The American Journal of Tropical Medicine and Hygiene·Olaf HorstickSilvia Runge Ranzinger
Nov 5, 2014·BMC Infectious Diseases·Shiran Ajith ParanavitaneGathsaurie Neelika Malavige
Apr 19, 2015·BMC Infectious Diseases·Cristina DomingoMatthias Niedrig

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Citations

Mar 13, 2017·BMC Infectious Diseases·Sibelle Nogueira BuonoraRita Maria Ribeiro Nogueira
Sep 28, 2017·Emerging Infectious Diseases·Sonia R Lambert PassosYara H M Hökerberg
Jun 28, 2018·Memórias do Instituto Oswaldo Cruz·Paulo Sousa PradoGustavo Adolfo Sierra Romero
Apr 26, 2019·Biomédica : revista del Instituto Nacional de Salud·Diana María CaicedoLyda Osorio
Feb 26, 2020·Journal of Clinical Nursing·Sibelle Nogueira BuonoraRaquel de Vasconcellos Carvalhaes de Oliveira
May 20, 2020·Diagnostics·Didier Musso, Philippe Despres
Aug 31, 2017·BMC Infectious Diseases·Verónica Elizabeth MataRaquel de Vasconcellos Carvalhaes de Oliveira
Jun 11, 2020·Cadernos de saúde pública·Verónica Elizabeth MataSuzana Alves da Silva
Jul 30, 2020·Healthcare·Min Cheol ChangDonghwi Park
Apr 29, 2020·The American Journal of Tropical Medicine and Hygiene·Diana María Caicedo-BorreroLyda Osorio
Aug 30, 2017·Micromachines·Ismail Hussain Kamal BashaNor Hisham Bin Hamid

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

MedCalc ©
SPSS
EpiData ©

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