Accuracy of computed tomography for detecting hepatic steatosis in donors for liver transplantation: A meta-analysis

Clinical Transplantation
Danping ZhengXiaoshun He

Abstract

The accuracy of computed tomography (CT) for detecting donor hepatic steatosis (HS) before liver transplantation is not well established. A meta-analysis was performed to determine the accuracy of CT for HS detection in liver donor candidates. Pooled sensitivity, specificity, positive and negative likelihood ratios, hierarchical summary receiver operating characteristic (HSROC) curves, and the area under the curve (AUC) were estimated using HSROC and bivariate random-effects models. Twelve studies involving 1782 subjects were eligible for this meta-analysis. For detecting significant HS (>10%-30% steatosis in liver pathology) with CT in liver donors, the pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were 0.81 (95% confidence interval [CI]: 0.70-0.89), 0.94 (95% CI: 0.90-0.96), 13.7 (95% CI: 8.1-23.1), and 0.20 (95% CI: 0.12-0.33). The AUC was 0.95 (95% CI: 0.92-0.96). For detecting the presence of HS, these corresponding diagnostic estimates were 0.50 (95% CI: 0.36-0.64), 0.90 (95% CI: 0.83-0.95), 5.2 (95% CI: 3.1-8.9), 0.55 (95% CI: 0.42-0.72), and 0.80 (95% CI: 0.76-0.83). Moderate-to-high heterogeneity was detected. Computed tomography shows high accuracy in detecting significant H...Continue Reading

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Citations

Jul 4, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ahad EshraghianSayed Ali Malek-Hosseini
Feb 16, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hyo Jung ParkSung-Gyu Lee
May 4, 2018·The British Journal of Radiology·Yingzhen N ZhangClaude B Sirlin
Feb 26, 2021·Scientific Reports·Bedriye Koyuncu SokmenNagihan Inan
Sep 22, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ahad EshraghianSeyed Ali Malek-Hosseini
Nov 10, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nilay DanisRohit Loomba

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