PMID: 11920903Mar 29, 2002Paper

Accuracy of Down syndrome risks produced in a first-trimester screening programme incorporating fetal nuchal translucency thickness and maternal serum biochemistry

Prenatal Diagnosis
K Spencer

Abstract

Over the past three years approximately 12 000 women have been screened in the first trimester through our OSCAR programme, which utilizes fetal NT and maternal serum free beta-hCG and PAPP-A. During this time 30 cases of Down syndrome were identified either prenatally or postnatally. Using an established procedure the accuracy of predicted risk for Down syndrome was assessed in a population of 30 cases of Down syndrome and 11 758 unaffected pregnancies. The correlation between predicted risk and prevalence of Down syndrome was very high (r=0.9995). It is concluded that risks produced by the Fetal Medicine Foundation combined risk algorithm agree very closely with Down syndrome prevalence and can be used with confidence when counselling women of their risk.

References

Jun 13, 1992·Lancet·K SpencerJ M Connor
Jan 1, 1996·Journal of Medical Screening·N J WaldA Kennard
Apr 16, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R J SnijdersK H Nicolaides
May 26, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Jun 17, 1999·Annals of Clinical Biochemistry·K Spencer

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Citations

Jul 13, 2002·Prenatal Diagnosis
Nov 27, 2008·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Robert CoccioloneKaren Shand
Nov 15, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·C HörmansdörferP Schmidt
Jun 15, 2012·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 15, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 1, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Nov 2, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J C Santiago, D Ramos-Corpas
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Jan 16, 2007·Journal of Medical Screening·N J WaldL M George
Nov 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Silvia So-Aei LiuSu-Chee Chen

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