Accuracy of early DMSA scan for VUR in young children with febrile UTI

Pediatrics
Xin ZhangYunli Bi

Abstract

To evaluate the accuracy of an acute (99m)Tc-dimercaptosuccinic acid (DMSA) scan in predicting dilating vesicoureteral reflux (VUR) among young children with a febrile urinary tract infection (UTI). The medical records of children (≤ 2 years of age), presenting with febrile UTI between January 2000 and December 2011, were retrospectively reviewed. A total of 523 children were included in this study, of whom 397 children (75.9%) had abnormal DMSA results and 178 children (34.0%) were identified as VUR on micturating cystourethrography (MCU). Among all the patients, the number of children with dilating VUR was 151 (28.9%). The rate of abnormal results on DMSA for the dilating VUR group was significantly higher than the rates for the non-VUR and low-grade VUR groups (P < .01). In the <6 months age group and ≥ 6 months age group, the sensitivities of DMSA in predicting dilating VUR were 96.15% and 100.0%, respectively, the negative predictive values were 97.26% and 100.0%, respectively, and the negative likelihood ratios were 0.0911 and 0.0000, respectively. For children ≤ 2 years of age with a febrile UTI, an acute DMSA scan is valuable in the exclusion of dilating VUR. The likelihood of the presence of dilating VUR on MCU is rath...Continue Reading

References

Jul 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I WikstadA Aperia
Feb 1, 1997·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H G Rushton
Nov 5, 1997·Pediatric Clinics of North America·E Shalaby-RanaM Majd
Jan 9, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·O Muga ZuriarrainR Areses Trapote
Jul 14, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hye-Young LeeSang Won Han
May 25, 2010·The Journal of Urology·Per BrandströmSverker Hansson
Nov 30, 2011·Acta Paediatrica·Anita AmmentiUNKNOWN Italian Society of Pediatric Nephrology
Jan 28, 2012·World Journal of Pediatrics : WJP·Nikoleta PrintzaFotios Papachristou

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Citations

Sep 14, 2014·Current Urology Reports·Pedro-Jose LopezRicardo Zubieta
Dec 5, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·A VachharajaniD E Coplen
May 18, 2016·Korean journal of pediatrics·Song Yi HanJae Il Shin
Apr 4, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Shina KawaiHideo Nakai
Jul 6, 2016·The Cochrane Database of Systematic Reviews·Nader ShaikhStephanie W Hum
Mar 22, 2018·World Journal of Pediatrics : WJP·Luke HarperCyril Ferdynus
Jun 15, 2017·Investigative and Clinical Urology·Ahmed Abdelhalim, Antoine E Khoury
Jul 13, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Shina KawaiToshinori Aihara
Apr 20, 2021·Frontiers in Pediatrics·Göran LäckgrenAndrew J Kirsch

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