Accuracy of exhaled nitric oxide measurements for the diagnosis of bronchiolitis obliterans syndrome after lung transplantation

Transplantation
Geert M VerledenLeuven Lung Transplant Group

Abstract

Exhaled nitric oxide (eNO) is increased in patients with bronchiolitis obliterans syndrome (BOS) after lung transplantation. However, the accuracy of eNO measurements in diagnosing BOS is unknown. Thirty-two lung-transplant patients were included. Their immunosuppressive regimen consisted of cyclosporin A (tacrolimus), azathioprine (mycophenolate mofetil), and oral but no inhaled steroids. eNO levels and spirometry were prospectively followed until 2 years after transplantation or until the patient developed BOS. Thirteen patients (group A) developed BOS (607 +/- 158 days after transplantation). Their mean eNO level at that time was 24.3 +/- 13.2 parts per billion (ppb), whereas the eNO value in the stable patients at 2 years (group B) was 11.4 +/- 4.9 ppb, P=0.0054. All group A patients had an eNO of 15 or greater ppb. Seven patients of group B also had an eNO of 15 or greater ppb, resulting in a test accuracy for the diagnosis of BOS of 0.78. However, considering only those patients who had two consecutive measurements (3-6 weeks apart) of eNO 15 or greater ppb during the months preceding the diagnosis of BOS or in the whole 2-year evaluation period, only 3 of 19 patients in group B (false-positives) but 12 of 13 in group A (...Continue Reading

References

Feb 1, 1995·The European Respiratory Journal·S A KharitonovP J Barnes
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Dec 1, 1995·The Annals of Thoracic Surgery·H ReichenspurnerB A Reitz
Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·L J DupontG M Verleden
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·A N HusainE R Garrity
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·M Reynaud-GaubertP Fuentes
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·J W van Den BERGE M ten VERGERT
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·M EstenneM Antoine
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·A De SoyzaP A Corris
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Mar 29, 2003·The European Respiratory Journal·G M VerledenM Demedts
Apr 12, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Steven D NathanNelson Burton
Jun 25, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elbert P TrulockMarshall I Hertz
Aug 12, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Geert M VerledenJohan Vanhaecke
Dec 13, 2003·American Journal of Respiratory and Critical Care Medicine·Ramsey R HachemElbert P Trulock

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Citations

Jan 20, 2007·American Journal of Respiratory and Critical Care Medicine·Alain Van MuylemMarc Estenne
Jan 1, 2013·Italian Journal of Pediatrics·Angelo MannaFrancesca Santamaria
Nov 3, 2009·Annals of Thoracic Medicine·Abdullah A Abba
Nov 5, 2013·Transplantation Proceedings·C BerasteguiA Román
Jul 17, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Meigui ZhouYixiang Duan
Apr 23, 2011·Clinics in Chest Medicine·Christiane Knoop, Marc Estenne
Dec 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M W H Pijnenburg, J C De Jongste
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L J DupontG M Verleden
Nov 23, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C NeurohrUNKNOWN Munich Lung Transplant Group
Jun 21, 2005·Respiratory Physiology & Neurobiology·Alain Van MuylemMarc Estenne
Nov 15, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R VosB M Vanaudenaerde
Dec 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mohamed A GashoutaReda E Girgis
Dec 18, 2015·European Clinical Respiratory Journal·Andrei MalinovschiZuzana Diamant

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