Accuracy of finite element analyses of CT scans in predictions of vertebral failure patterns under axial compression and anterior flexion

Journal of Biomechanics
Timothy M JackmanElise F Morgan

Abstract

Finite element (FE) models built from quantitative computed tomography (QCT) scans can provide patient-specific estimates of bone strength and fracture risk in the spine. While prior studies demonstrate accurate QCT-based FE predictions of vertebral stiffness and strength, the accuracy of the predicted failure patterns, i.e., the locations where failure occurs within the vertebra and the way in which the vertebra deforms as failure progresses, is less clear. This study used digital volume correlation (DVC) analyses of time-lapse micro-computed tomography (μCT) images acquired during mechanical testing (compression and anterior flexion) of thoracic spine segments (T7-T9, n=28) to measure displacements occurring throughout the T8 vertebral body at the ultimate point. These displacements were compared to those simulated by QCT-based FE analyses of T8. We hypothesized that the FE predictions would be more accurate when the boundary conditions are based on measurements of pressure distributions within intervertebral discs of similar level of disc degeneration vs. boundary conditions representing rigid platens. The FE simulations captured some of the general, qualitative features of the failure patterns; however, displacement errors ...Continue Reading

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Citations

Oct 25, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Hannah M GustafsonBenedikt Helgason
Mar 14, 2020·Nature Biomedical Engineering·Mariana E Kersh
Sep 12, 2019·Biomechanics and Modeling in Mechanobiology·Yuanqiao Wu, Elise F Morgan
Nov 21, 2020·Current Osteoporosis Reports·Joshua D AugerElise F Morgan
Mar 7, 2021·Bioengineering·André P G Castro
Nov 6, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kenneth Es PooleTristan Whitmarsh

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